Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | PYGL | P06737 | 1/20 | 0.32 |
| ▸ | PYGM | P11217 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | FNTA | P49354 | 1/20 | 0.30 |
| ▸ | FNTB | P49356 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7494164 | 0.92 | KDM4E (0.35) | CCR3KDM4EALDH1A1CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL7498615 | 0.91 | KDM4E (0.34) | CCR3KDM4EALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL8303663 | 0.84 | KDM4E (0.33) | CCR3KDM4EALDH1A1CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL8189910 | 0.84 | KDM4E (0.34) | CCR3KDM4EALDH1A1CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL8189914 | 0.84 | KDM4E (0.34) | CCR3KDM4EALDH1A1CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL7499272 | 0.84 | KDM4E (0.33) | CCR3KDM4EALDH1A1CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL8038219 | 0.84 | KDM4E (0.33) | CCR3KDM4EALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL6947162 | 0.82 | RXFP1 (0.35) | CCR3KDM4EALDH1A1PYGLPYGM | |
| SCHEMBL8191683 | 0.81 | KDM4E (0.38) | CCR3KDM4EALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL8191680 | 0.81 | KDM4E (0.38) | CCR3KDM4EALDH1A1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6131226-A | 2-SUBSTITUTED,3,5-BIS(METHOXYCARBONYL),4-(2,6-DIHALOPHENYL), 6-(1-((SUBSTITUTED)RING)PIPERAZIN-1,4-YLENE-CARBONYLMETHYL)-1, 4-DIHYDROPYRIDINES; FOR TREATING INFLAMMATION, PAIN, VIRAL INFECTIONS, CARDIOVASCULAR DISEASE, ALLERGIES, ASTHMA | PFIZER INC. (US) | 2000-10-17 | — | — | US | disclosed |