Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.35 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.33 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.33 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | PYGL | P06737 | 1/20 | 0.33 |
| ▸ | PYGM | P11217 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | ACACA | Q13085 | 1/20 | 0.31 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6946279 | 0.92 | RXFP1 (0.37) | RXFP1CCR3TPSAB1TPSD1TPSG1 | |
| SCHEMBL6948042 | 0.85 | RXFP1 (0.35) | RXFP1CCR3TPSAB1TPSD1TPSG1 | |
| SCHEMBL8049632 | 0.82 | CCR3 (0.35) | CCR3MEN1KMT2APYGLPYGM | |
| SCHEMBL6948051 | 0.80 | RXFP1 (0.37) | RXFP1CCR3TPSAB1TPSD1TPSG1 | |
| SCHEMBL6943528 | 0.80 | CCR3 (0.36) | CCR3MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL6152408 | 0.80 | CCR3 (0.36) | CCR3MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL6947171 | 0.80 | CCR3 (0.34) | CCR3MGLLALDH1A1KDM4ECHRM2 | |
| SCHEMBL7838559 | 0.78 | SIGMAR1 (0.42) | CCR3MEN1KMT2AMGLLALDH1A1 | |
| SCHEMBL6153146 | 0.78 | CCR3 (0.34) | CCR3MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL6152430 | 0.77 | CCR3 (0.34) | CCR3MEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307449-A1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002012235-A1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 2002-02-14 | — | — | WO | disclosed |