Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8050828 | 0.86 | ALDH1A1 (0.48) | ALDH1A1HSD17B10MAPTHPGDMEN1 | |
| SCHEMBL8041828 | 0.85 | ALDH1A1 (0.41) | ALDH1A1HSD17B10MAPTHPGDMEN1 | |
| SCHEMBL8050049 | 0.85 | ALDH1A1 (0.41) | ALDH1A1HSD17B10MAPTHPGDMEN1 | |
| SCHEMBL8045824 | 0.85 | ALDH1A1 (0.41) | ALDH1A1HSD17B10MAPTHPGDMEN1 | |
| SCHEMBL8042692 | 0.83 | POLB (0.46) | ALDH1A1HSD17B10MAPTHPGDMEN1 | |
| SCHEMBL8051515 | 0.82 | HPGD (0.49) | ALDH1A1HSD17B10MAPTHPGDMEN1 | |
| SCHEMBL8042315 | 0.82 | KMT2A (0.46) | ALDH1A1HSD17B10MAPTHPGDMEN1 | |
| SCHEMBL8051230 | 0.81 | TP53 (0.46) | ALDH1A1HSD17B10MAPTHPGDMEN1 | |
| SCHEMBL8050797 | 0.81 | MAPK1 (0.40) | ALDH1A1HSD17B10MAPTHPGDMEN1 | |
| SCHEMBL8049831 | 0.81 | HDAC6 (0.38) | ALDH1A1HSD17B10MAPTHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |