Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 1/20 | 0.87 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.87 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.69 |
| ▸ | MEN1 | O00255 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | GAA | P10253 | 2/20 | 0.69 |
| ▸ | PKM | P14618 | 2/20 | 0.69 |
| ▸ | HPGD | P15428 | 2/20 | 0.69 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.69 |
| ▸ | SREBF2 | Q12772 | 2/20 | 0.60 |
| ▸ | AR | P10275 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | CASP3 | P42574 | 1/20 | 0.59 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1180078 | 0.93 | HSD17B1 (1.00) | HSD17B1HSD17B2CYP19A1SMN1; SMN2KDM4E | |
| SCHEMBL1181077 | 0.92 | HSD17B1 (0.84) | HSD17B1HSD17B2CYP19A1SMN1; SMN2KDM4E | |
| SCHEMBL8057629 | 0.90 | HSD17B1 (0.82) | HSD17B1HSD17B2CYP19A1SMN1; SMN2KDM4E | |
| SCHEMBL4267715 | 0.86 | KDM4E (0.68) | HSD17B1HSD17B2CYP19A1SMN1; SMN2KDM4E | |
| SCHEMBL1180965 | 0.85 | HSD17B1 (0.84) | HSD17B1HSD17B2CYP19A1SMN1; SMN2KDM4E | |
| SCHEMBL19195912 | 0.84 | SMN1; SMN2 (0.66) | HSD17B1HSD17B2CYP19A1SMN1; SMN2KDM4E | |
| SCHEMBL8052755 | 0.83 | HSD17B1 (0.75) | HSD17B1HSD17B2CYP19A1SMN1; SMN2KDM4E | |
| SCHEMBL8040175 | 0.83 | CYP19A1 (0.74) | HSD17B1HSD17B2CYP19A1SMN1; SMN2KDM4E | |
| SCHEMBL6330424 | 0.83 | SREBF2 (0.70) | HSD17B1HSD17B2CYP19A1SMN1; SMN2KDM4E | |
| SCHEMBL8051375 | 0.83 | SREBF2 (0.70) | HSD17B1HSD17B2CYP19A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130217-A | ANTITUMOR | PFIZER INC (US) | 2000-10-10 | — | — | US | disclosed |
| WO-1994022846-A1 | COMPOUNDS ENHANCING ANTITUMOR ACTIVITY OF OTHER CYTOTOXIC AGENTS | PFIZER INC. (US) | 1994-10-13 | — | — | WO | disclosed |