Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 15/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GGPS1 | O95749 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8049638 | 0.92 | FDPS (0.61) | FDPSPDE3ALMNAADRB3PDE4D | |
| SCHEMBL8048221 | 0.82 | FDPS (0.50) | FDPSPDE3ALMNAADRB3PDE4D | |
| SCHEMBL8038317 | 0.79 | FDPS (0.58) | FDPSPDE3ALMNAADRB3PDE4D | |
| SCHEMBL15022604 | 0.78 | FDPS (0.38) | FDPSPDE3ALMNAADRB3PDE4D | |
| SCHEMBL8038000 | 0.74 | FDPS (0.47) | FDPSPDE3ALMNAADRB3PDE4D | |
| SCHEMBL8038146 | 0.74 | FDPS (0.47) | FDPSPDE3ACA12CA1CA2 | |
| SCHEMBL9115357 | 0.73 | TSHR (0.46) | FDPSLMNACA12CA1CA2 | |
| SCHEMBL8048146 | 0.73 | FDPS (0.60) | FDPSPDE3AGGPS1 | |
| SCHEMBL20178996 | 0.72 | LMNA (0.52) | FDPSLMNACA12CA1CA2 | |
| SCHEMBL11737002 | 0.72 | TSHR (0.43) | FDPSLMNACA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0563096-B1 | NOVEL METHYLENEBISPHOSPHONIC ACID DERIVATIVES | LEIRAS OY (FI) | 2000-05-03 | — | — | EP | disclosed |
| US-5438048-A | Used for treatment of disorders related to metabolism of calcium and other bivalent metals; treats bone cancer, urolithiasis, rheumatoid arthritis, bone infection and bone degradation | LEIRAS OY (FI) | 1995-08-01 | — | — | US | disclosed |
| WO-1992011267-A1 | NOVEL METHYLENEBISPHOSPHONIC ACID DERIVATIVES | LEIRAS OY (FI) | 1992-07-09 | — | — | WO | disclosed |