Sugi Predict

Sugi Predict / Compounds / SCHEMBL8050356

SCHEMBL8050356

SCHEMBL8050356

CCOC(=O)/C=C/c1ccccc1C#N

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.48
▸ GAA P10253 1/20 0.48
▸ L3MBTL1 Q9Y468 1/20 0.48
▸ CA12 O43570 1/20 0.48
▸ CA1 P00915 1/20 0.48
▸ CA2 P00918 1/20 0.48
▸ CA7 P43166 1/20 0.48
▸ CA9 Q16790 1/20 0.48
▸ CA14 Q9ULX7 1/20 0.48
▸ NLRP3 Q96P20 1/20 0.45
▸ TTR P02766 1/20 0.44
▸ DPP4 P27487 1/20 0.44
▸ CYP3A4 P08684 2/20 0.44
▸ CCNC P24863 1/20 0.44
▸ CDK8 P49336 1/20 0.44
▸ NPC1 O15118 1/20 0.43
▸ RAB9A P51151 1/20 0.43
▸ MAPT P10636 5/20 0.43
▸ LMNA P02545 1/20 0.43
▸ MDM2 Q00987 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5317693 1.00 ALDH1A1 (0.48) ALDH1A1GAAL3MBTL1CA12CA1
SCHEMBL1399174 0.90 GAA (0.48) ALDH1A1GAAL3MBTL1CA12CA1
SCHEMBL1399096 0.90 GAA (0.48) ALDH1A1GAAL3MBTL1CA12CA1
SCHEMBL28414558 0.89 CCNC (0.46) ALDH1A1GAAL3MBTL1CA12CA1
SCHEMBL28645173 0.89 APP (0.47) ALDH1A1GAAL3MBTL1LMNAKDM4E
SCHEMBL28653578 0.89 APP (0.47) ALDH1A1GAAL3MBTL1LMNAKDM4E
SCHEMBL4623066 0.86 APP (0.49) ALDH1A1L3MBTL1MAPTKDM4EHPGD
SCHEMBL4623064 0.86 APP (0.49) ALDH1A1L3MBTL1MAPTKDM4EHPGD
SCHEMBL28650880 0.85 ALDH1A1 (0.42) ALDH1A1GAAL3MBTL1MAPTLMNA
SCHEMBL28650877 0.85 ALDH1A1 (0.42) ALDH1A1GAAL3MBTL1MAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10723998-B2 Application of ethyl p-methoxycinnamate and derivatives thereof in maintaining self-renewal and pluripotency of stem cells NORTHEAST NORMAL UNIVERSITY (CN) 2020-07-28 — — US claimed
US-20180195039-A1 APPLICATION OF ETHYL P-METHOXYCINNAMATE AND DERIVATIVES THEREOF IN MAINTAINING SELF-RENEWAL AND PLURIPOTENCY OF STEM CELLS NORTHEAST NORMAL UNIVERSITY (CN) 2018-07-12 — — US claimed
WO-2023079780-A1 TEMPERATURE INDICATOR MANUFACTURING SYSTEM AND TEMPERATURE INDICATOR MANUFACTURING METHOD 株式会社日立産機システム 2023-05-11 — — WO disclosed
CN-112495438-B Preparation method of super-strong fiber loaded acid-base bifunctional catalyst 河南理工大学 2023-04-07 — — CN disclosed
US-20220002278-A9 HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF SUZHOU INSTITUTE OF MATERIA MEDICA (CN) 2022-01-06 — — US disclosed
CN-110248971-B Copolymer and optical film using the same 东曹株式会社 2021-11-02 — — CN disclosed
US-20210101891-A1 HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF SHANGHAI INST MATERIA MEDICA CAS (CN) 2021-04-08 — — US disclosed
CN-112495438-A Preparation method of super-strong fiber loaded acid-base bifunctional catalyst 河南理工大学 2021-03-16 — — CN disclosed
US-10723998-B2 Application of ethyl p-methoxycinnamate and derivatives thereof in maintaining self-renewal and pluripotency of stem cells NORTHEAST NORMAL UNIVERSITY (CN) 2020-07-28 — — US disclosed
WO-2019201291-A1 HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF 中国科学院上海药物研究所 2019-10-24 — — WO disclosed
US-20180195039-A1 APPLICATION OF ETHYL P-METHOXYCINNAMATE AND DERIVATIVES THEREOF IN MAINTAINING SELF-RENEWAL AND PLURIPOTENCY OF STEM CELLS NORTHEAST NORMAL UNIVERSITY (CN) 2018-07-12 — — US disclosed
CN-103002735-A Modulators of 5-ht receptors and methods of use thereof ABBVI CO 2013-03-27 — — CN disclosed
CN-102746214-A Novel indoline compounds FOURNIER LAB SA 2012-10-24 — — CN disclosed
CN-101184731-A Indoline compounds FOURNIER LAB SA (FR) 2008-05-21 — — CN disclosed
EP-0866786-B1 BASIC CATALYSTS FOR THE ALDOL REACTION NOVARTIS AG (CH) 2000-05-10 — — EP disclosed
US-5977290-A Basic catalysts for the aldol reaction NOVARTIS AG (CH) 1999-11-02 — — US disclosed
EP-0870750-A2 Catalyst for reactions of the aldol type Novartis AG (CH) 1998-10-14 — — EP disclosed
EP-0866786-A1 BASIC CATALYSTS FOR THE ALDOL REACTION Novartis AG (CH) 1998-09-30 — — EP disclosed
WO-1997021659-A1 BASIC CATALYSTS FOR THE ALDOL REACTION NOVARTIS AG (CH) 1997-06-19 — — WO disclosed
US-4564479-A PALLADIUM COMPOUND, PHOSPHORUS OR ARSENIC COMPOUND CIBA-GEIGY CORPORATION (US) 1986-01-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180195039-A1 APPLICATION OF ETHYL P-METHOXYCINNAMATE AND DERIVATIVES THEREOF IN MAINTAINING SELF-RENEWAL AND PLURIPOTENCY OF STEM CELLS XPA, MEP1A, EED ALDH1A1 107/4885GAA 3596/4885L3MBTL1 814/4885
US-10723998-B2 Application of ethyl p-methoxycinnamate and derivatives thereof in maintaining self-renewal and pluripotency of stem cells XPA, MEP1A, EED ALDH1A1 107/4885GAA 3596/4885L3MBTL1 814/4885
US-20210101891-A1 HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF EP300, HDAC11, HDAC1 ALDH1A1 654/4885GAA 336/4885L3MBTL1 1686/4885
US-20220002278-A9 HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF EP300, HDAC11, HDAC1 ALDH1A1 654/4885GAA 336/4885L3MBTL1 1686/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.