Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | ESR1 | P03372 | 1/20 | 0.62 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.62 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.62 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | GGT1 | P19440 | 1/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.62 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9371271 | 0.85 | MAPK1 (0.66) | PTGS2KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL12572402 | 0.84 | PTGS2 (0.65) | PTGS2KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL16058883 | 0.83 | HPGDS (0.46) | PTGS2KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL11017487 | 0.83 | PTGS2 (0.74) | PTGS2KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL17479842 | 0.82 | PTPN1 (0.47) | PTGS2KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL18922721 | 0.82 | PTGS2 (0.62) | PTGS2KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL29419354 | 0.81 | HPGDS (0.65) | HPGDALDH1A1LMNAKMT2AHPGDS | |
| SCHEMBL169081 | 0.81 | HPGDS (0.65) | HPGDALDH1A1LMNAKMT2AHPGDS | |
| SCHEMBL12248113 | 0.81 | PTGS2 (0.61) | PTGS2KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL10457143 | 0.81 | PTGS2 (0.66) | PTGS2KDM4EHSD17B10HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970282-A1 | TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS | Incyte Corporation (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014143768-A1 | TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS | INCYTE CORPORATION (US) | 2014-09-18 | — | — | WO | disclosed |
| US-6130217-A | ANTITUMOR | PFIZER INC (US) | 2000-10-10 | — | — | US | disclosed |
| WO-1994022846-A1 | COMPOUNDS ENHANCING ANTITUMOR ACTIVITY OF OTHER CYTOTOXIC AGENTS | PFIZER INC. (US) | 1994-10-13 | — | — | WO | disclosed |
| US-4497817-A | ANTIALLERGENS-IMMUNOSUPPRESSIVE AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1985-02-05 | — | — | US | disclosed |