Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 16/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8053053 | 1.00 | ELANE (0.64) | ELANECYP2C9CYP3A4ADRB1HTR1A | |
| SCHEMBL9914390 | 0.91 | ELANE (0.64) | ELANECYP2C9CYP3A4ADRB1HTR1A | |
| SCHEMBL8052101 | 0.91 | ELANE (0.52) | ELANECYP2C9CYP3A4ADRB1HTR1A | |
| SCHEMBL8050837 | 0.89 | ELANE (0.79) | ELANECYP2C9CYP3A4ADRB1HTR1A | |
| SCHEMBL6295870 | 0.89 | ELANE (0.81) | ELANECYP2C9CYP3A4 | |
| SCHEMBL1134170 | 0.89 | ELANE (0.81) | ELANECYP2C9CYP3A4 | |
| SCHEMBL14899945 | 0.86 | ELANE (0.66) | ELANECYP2C9CYP3A4ADRB1HTR1A | |
| SCHEMBL9914389 | 0.85 | ELANE (0.68) | ELANECYP2C9CYP3A4ADRB1HTR1A | |
| SCHEMBL2887923 | 0.82 | ELANE (0.79) | ELANECYP2C9CYP3A4ADRB1HTR1A | |
| SCHEMBL8220267 | 0.81 | ELANE (0.80) | ELANECYP2C9CYP3A4ADRB1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007129060-A1 | TETRAHYDROPYRROLOPYRIMIDINEDIONES AND THEIR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS | ARGENTA DISCOVERY LIMITED (GB) | 2007-11-15 | — | — | WO | disclosed |