Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | ACACA | Q13085 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042926 | 0.77 | MEN1 (0.34) | SMN1; SMN2ALDH1A1L3MBTL1KMT2ACYP1A2 | |
| SCHEMBL8050555 | 0.76 | RPS6KB2 (0.39) | SMN1; SMN2ALDH1A1TSHRL3MBTL1GAA | |
| SCHEMBL8050345 | 0.73 | KMT2A (0.38) | SMN1; SMN2ALDH1A1L3MBTL1POLBKMT2A | |
| SCHEMBL8044768 | 0.73 | KMT2A (0.45) | SMN1; SMN2ALDH1A1TSHRL3MBTL1GAA | |
| SCHEMBL13141342 | 0.73 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1TSHRL3MBTL1GAA | |
| SCHEMBL8049900 | 0.72 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1TSHRL3MBTL1GAA | |
| SCHEMBL27714449 | 0.71 | APP (0.46) | SMN1; SMN2ALDH1A1TRPM8KMT2AKDM4E | |
| SCHEMBL16563690 | 0.71 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1TSHRL3MBTL1GAA | |
| SCHEMBL16564352 | 0.71 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1TSHRL3MBTL1GAA | |
| SCHEMBL27770429 | 0.70 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1TSHRL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |