Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8050345 | 0.77 | KMT2A (0.38) | KMT2ATDP1PKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL8049900 | 0.75 | SMN1; SMN2 (0.41) | KMT2ATDP1PKMHSD17B10SMN1; SMN2 | |
| SCHEMBL8043885 | 0.74 | KMT2A (0.40) | KMT2ATDP1PKMHSD17B10SMN1; SMN2 | |
| SCHEMBL2239852 | 0.74 | PKM (0.53) | KMT2ATDP1PKMHSD17B10SMN1; SMN2 | |
| SCHEMBL8051645 | 0.73 | SMN1; SMN2 (0.43) | KMT2ATDP1HSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL2237183 | 0.72 | PKM (0.51) | KMT2ATDP1PKMHSD17B10SMN1; SMN2 | |
| SCHEMBL26308848 | 0.71 | PKM (0.50) | KMT2ATDP1PKMHSD17B10SMN1; SMN2 | |
| SCHEMBL8050555 | 0.69 | RPS6KB2 (0.39) | KMT2APKMSMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL20157276 | 0.69 | PKM (0.48) | KMT2ATDP1PKMHSD17B10SMN1; SMN2 | |
| SCHEMBL5180007 | 0.69 | KMT2A (0.51) | KMT2ATDP1PKMHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |