⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7262869 | 0.78 | — | — | |
| SCHEMBL1994157 | 0.76 | — | — | |
| SCHEMBL16992903 | 0.73 | — | — | |
| SCHEMBL8670493 | 0.73 | HCAR2 (0.38) | — | |
| SCHEMBL9851139 | 0.72 | — | — | |
| SCHEMBL2840244 | 0.72 | — | — | |
| SCHEMBL14877408 | 0.71 | — | — | |
| SCHEMBL8670495 | 0.71 | ALOX5 (0.43) | — | |
| SCHEMBL8806436 | 0.69 | ALOX5 (0.36) | — | |
| SCHEMBL8198507 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2670406-B1 | COMBINATION THERAPY WITH INTERFERON BETA AND ANDROGRAPHOLIDES FOR MULTIPLE SCLEROSIS | INNOBIOSCIENCE LLC (US) | 2015-09-02 | — | — | EP | claimed |
| US-9060994-B2 | Combination therapy with interferon and andrographolides for Multiple Sclerosis | Inno Biosciences, S.p.A. (CL) | 2015-06-23 | — | — | US | claimed |
| US-20140301981-A1 | Combination Therapy with Interferon and Andrographolides for Multiple Sclerosis | INNOBIOSCIENCE LLC (US) | 2014-10-09 | — | — | US | claimed |
| EP-2670406-A1 | COMBINATION THERAPY WITH INTERFERON AND ANDROGRAPHOLIDES FOR MULTIPLE SCLEROSIS | Herbal Powers Corporation (US) | 2013-12-11 | — | — | EP | claimed |
| WO-2013096423-A1 | COMBINATION THERAPY WITH INTERFERON AND ANDROGRAPHOLIDES FOR MULTIPLE SCLEROSIS | Herbal Powers Corporation (US) | 2013-06-27 | — | — | WO | claimed |
| US-20220409573-A1 | Hippocampus Regeneration And Memory Recovery | INNOBIOSCIENCE, LLC (US) | 2022-12-29 | — | — | US | disclosed |
| CN-109562097-B | Progressive forms of andrographolide for treating multiple sclerosis | 因诺生物科学有限责任公司 | 2022-06-07 | — | — | CN | disclosed |
| US-10722492-B2 | Andrographolide treats progressive forms of multiple sclerosis | Inno Bioscience, LLC (US) | 2020-07-28 | — | — | US | disclosed |
| US-20190083458-A1 | Andrographolide Treats Progressive Forms of Multiple Sclerosis | INNOBIOSCIENCES, LLC (US) | 2019-03-21 | — | — | US | disclosed |
| US-9060994-B2 | Combination therapy with interferon and andrographolides for Multiple Sclerosis | Inno Biosciences, S.p.A. (CL) | 2015-06-23 | — | — | US | disclosed |
| US-20140301981-A1 | Combination Therapy with Interferon and Andrographolides for Multiple Sclerosis | INNOBIOSCIENCE LLC (US) | 2014-10-09 | — | — | US | disclosed |
| US-6040449-A | USEFUL FOR FORMING FLUORINE CONTAINING 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES, USEFUL AS ANTAGONIST FOR MUSCARINIC M3 RECEPTORS AND LESS SIDE EFFECT | BANYU PHARMACEUTICAL CO LTD (JP) | 2000-03-21 | — | — | US | disclosed |
| US-5948792-A | POTENT AND SELECTIVE ANTAGONISTS FOR MUSCARINIC M.SUB.3 RECEPTORS WITH LITTLE SIDE EFFECTS. | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1999-09-07 | — | — | US | disclosed |
| EP-0930298-A1 | FLUORINATED 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1999-07-21 | — | — | EP | disclosed |