Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.51 |
| ▸ | TSHR | P16473 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | FBP1 | P09467 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.43 |
| ▸ | SI | P14410 | 1/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044143 | 0.85 | ALDH1A1 (0.45) | ALDH1A1TSHRHPGDL3MBTL1MAPK1 | |
| SCHEMBL8041814 | 0.85 | KMT2A (0.43) | ALDH1A1TSHRHPGDL3MBTL1MAPK1 | |
| SCHEMBL8042104 | 0.84 | ALDH1A1 (0.52) | ALDH1A1TSHRHPGDL3MBTL1MAPK1 | |
| SCHEMBL8033776 | 0.84 | HSP90AA1 (0.44) | ALDH1A1TSHRHPGDL3MBTL1MAPK1 | |
| SCHEMBL8043251 | 0.82 | ALDH1A1 (0.49) | ALDH1A1TSHRHPGDL3MBTL1MAPK1 | |
| SCHEMBL8033926 | 0.81 | ALDH1A1 (0.43) | ALDH1A1TSHRHPGDL3MBTL1MAPK1 | |
| SCHEMBL8046562 | 0.80 | ALDH1A1 (0.70) | ALDH1A1TSHRHPGDL3MBTL1MAPK1 | |
| SCHEMBL8044261 | 0.79 | ALDH1A1 (0.50) | ALDH1A1TSHRHPGDL3MBTL1MAPK1 | |
| SCHEMBL8033566 | 0.79 | ALDH1A1 (0.45) | ALDH1A1TSHRHPGDL3MBTL1MAPK1 | |
| SCHEMBL8043867 | 0.78 | ALDH1A1 (0.45) | ALDH1A1TSHRHPGDL3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |