Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043031 | 0.88 | KMT2A (0.45) | KMT2ALMNATP53MAPTHTT | |
| SCHEMBL8052304 | 0.86 | ALDH1A1 (0.49) | KMT2ALMNATP53MAPTHTT | |
| SCHEMBL8052302 | 0.85 | ALDH1A1 (0.51) | KMT2ALMNATP53MAPTHTT | |
| SCHEMBL8042104 | 0.84 | ALDH1A1 (0.52) | KMT2ALMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL8044143 | 0.83 | ALDH1A1 (0.45) | KMT2ALMNATP53MAPTHTT | |
| SCHEMBL8043670 | 0.82 | PKM (0.44) | KMT2ALMNATP53MAPTHTT | |
| SCHEMBL8045225 | 0.82 | KMT2A (0.46) | KMT2ALMNATP53MAPTHTT | |
| SCHEMBL8044412 | 0.82 | SMN1; SMN2 (0.44) | KMT2ALMNATP53MAPTHTT | |
| SCHEMBL8042716 | 0.82 | ALDH1A1 (0.52) | KMT2ALMNATP53MAPTHTT | |
| SCHEMBL8032425 | 0.81 | ALDH1A1 (0.41) | KMT2ALMNATP53MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |