Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8049755 | 0.87 | LSS (0.46) | LSSMAOBNPC1MAPTRAB9A | |
| SCHEMBL9360246 | 0.86 | LSS (0.46) | LSSNPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL8045307 | 0.85 | LSS (0.46) | LSSNPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL8035630 | 0.85 | LSS (0.60) | LSSMAOBNPC1MAPTRAB9A | |
| SCHEMBL8046483 | 0.83 | LSS (0.44) | LSSNPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL8035335 | 0.81 | LSS (0.48) | LSSMAOBMAPTSMN1; SMN2SRD5A2 | |
| SCHEMBL8047698 | 0.77 | SRD5A2 (0.47) | LSSMAOBSRD5A2ALDH1A1CYP1A1 | |
| SCHEMBL8902485 | 0.77 | SRD5A2 (0.47) | LSSMAOBSRD5A2ALDH1A1CYP1A1 | |
| SCHEMBL7772016 | 0.77 | LSS (0.38) | LSSNPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL8045026 | 0.77 | MAPT (0.48) | LSSNPC1MAPTRAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636367-B1 | Use of phenylalkylamines for producing cholesterol lowering agents | HOFFMANN LA ROCHE (CH) | 2000-03-29 | — | — | EP | claimed |