Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 1/20 | 0.43 |
| ▸ | FAP | Q12884 | 1/20 | 0.43 |
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
| ▸ | CPA1 | P15085 | 1/20 | 0.41 |
| ▸ | CPA2 | P48052 | 1/20 | 0.41 |
| ▸ | CPA4 | Q9UI42 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | ACE | P12821 | 8/20 | 0.39 |
| ▸ | REN | P00797 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PEPD | P12955 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8053098 | 1.00 | PREP (0.43) | PREPFAPXIAPCPA1CPA2 | |
| SCHEMBL11760610 | 0.85 | ACE (0.54) | PREPFAPF2ACEREN | |
| SCHEMBL8053385 | 0.85 | ACE (0.54) | PREPFAPF2ACEREN | |
| SCHEMBL8054194 | 0.83 | PREP (0.41) | PREPFAPXIAPCPA1CPA2 | |
| SCHEMBL8054196 | 0.83 | PREP (0.41) | PREPFAPXIAPCPA1CPA2 | |
| SCHEMBL31181299 | 0.82 | CPA1 (0.47) | PREPFAPXIAPCPA1CPA2 | |
| SCHEMBL9002891 | 0.82 | PREP (0.57) | PREPFAPXIAPF2ACE | |
| SCHEMBL11567385 | 0.80 | PREP (0.45) | PREPFAPXIAPCPA1CPA2 | |
| SCHEMBL8052318 | 0.79 | PREP (0.42) | PREPFAPXIAPCPA1CPA2 | |
| SCHEMBL8052315 | 0.79 | PREP (0.42) | PREPFAPXIAPCPA1CPA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130315-A | SUBSTRATES IN WHICH THE SCISSILE AMIDE BOND HAS BEEN REPLACED BY AN ACTIVATED ELECTROPHILIC KETONE MOIETY; ANTIINFLAMMATORY AGENTS; ANTIPROLIFERATIVE/ANTICARCINOGENIC/ANTIARTHRITIC AGENTS; TREATMENT OF AUTOIMMUNE DISEASES | MERRELL PHARMACEUTICALS INC. (US) | 2000-10-10 | — | — | US | disclosed |
| US-5496927-A | INHIBITORS OF HUMAN LEUKOCYTE ELASTASE, CATHEPSIN G, CHYMOTRYPSIN | MERRELL PHARMACEUTICALS INC. (US) | 1996-03-05 | — | — | US | disclosed |
| EP-0195212-B1 | Novel peptidase inhibitors | MERRELL DOW PHARMA (US) | 1993-11-24 | — | — | EP | disclosed |
| EP-0195212-A2 | Novel peptidase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-09-24 | — | — | EP | disclosed |