Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | SI | P14410 | 4/20 | 0.45 |
| ▸ | MGAM2 | Q2M2H8 | 4/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9586132 | 0.92 | GAA (0.44) | MGAMGAASIMGAM2 | |
| SCHEMBL9397560 | 0.89 | GAA (0.41) | MGAMGAASIMGAM2TBXA2R | |
| SCHEMBL8530545 | 0.88 | ALKBH2 (0.43) | — | |
| SCHEMBL8532771 | 0.88 | — | — | |
| SCHEMBL9395095 | 0.88 | GAA (0.40) | MGAMGAASIMGAM2 | |
| SCHEMBL14862819 | 0.87 | — | — | |
| SCHEMBL9397577 | 0.87 | GAA (0.40) | MGAMGAASIMGAM2 | |
| SCHEMBL9586684 | 0.85 | MGAM (0.38) | MGAMGAASIMGAM2 | |
| SCHEMBL3676853 | 0.81 | GABRP (0.46) | — | |
| SCHEMBL9472452 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143775-A | PHYSICAL FORM OF ZAFIRLUKAST; ASTHMA | ZENECA LIMITED (GB) | 2000-11-07 | — | — | US | disclosed |
| US-5993859-A | N-(4-(5-(CYCLOPENTYLOXYCARBONYL)AMINO-1-METHYLINDOL-3-YL-METHY L)-3-METHOXY BENZOYL)-2-METHYL-BENZENESULPHONAMIDE AND POLYVINYLPYRROLIDONE. | ZENECA LIMITED (GB) | 1999-11-30 | — | — | US | disclosed |
| US-5612367-A | Orally administering an amorphous physical form of zafirlukast in combination with polyvinylpyrrolidone | ZENECA LIMITED (GB) | 1997-03-18 | — | — | US | disclosed |
| EP-0490649-B1 | A physical form of N-[4-[5-(cyclopentyloxycarbonylamino)-1-methyl-indol-3-ylmethyl]-3-methoxybenzoyl]-2-methylbenzenesulfonamide, a process for its preparation and pharmaceutical compositions containing it | ZENECA LTD (GB) | 1996-11-13 | — | — | EP | disclosed |
| US-5504216-A | DEHYDRATING WITH HEATING UNDER REDUCED PRESSURE | ZENECA LIMITED (GB) | 1996-04-02 | — | — | US | disclosed |
| US-5482963-A | Physical form of N-(4-(5(cyclopentyloxycarbonyl)amino-1-methylindol-3-yl -methyl)3methoxybenzoyl)-2-methylbenzenesulphonamide, zafirlukast; tablet; asthma | ZENECA LIMITED (GB) | 1996-01-09 | — | — | US | disclosed |
| EP-0490648-B1 | Pharmaceutical agents | ZENECA LTD (GB) | 1995-12-06 | — | — | EP | disclosed |
| US-5319097-A | Physical form of leukotriene antagonist such as zafirlukast, N-(4-(5-(cyclopentyloxycarbonyl)amino-1-methylindol-3-yl-methyl)-3-methoxybenzoyl)-2methylbenzenesulfonamide; spray drying in acetone | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-06-07 | — | — | US | disclosed |
| US-5294636-A | Such as zafirlukast; leukotriene antagonist; metered dose inhalers | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-03-15 | — | — | US | disclosed |
| EP-0490649-A1 | A physical form of N-[4-[5-(cyclopentyloxycarbonylamino)-1-methyl-indol-3-ylmethyl]-3-methoxybenzoyl]-2-methylbenzenesulfonamide, a process for its preparation and pharmaceutical compositions containing it | ZENECA LIMITED (GB) | 1992-06-17 | — | — | EP | disclosed |
| EP-0490648-A1 | Pharmaceutical agents | ZENECA LIMITED (GB) | 1992-06-17 | — | — | EP | disclosed |