Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | SCN4A | P35499 | 2/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.34 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9850761 | 0.96 | SNCA (0.44) | SNCAHIF1ASCN4ATAAR1SLC6A2 | |
| Hydrochloric Acid SCHEMBL28196291 | 0.93 | SNCA (0.42) | SNCAHIF1ASCN4ATAAR1SLC6A2 | |
| Hydrochloric Acid SCHEMBL11410207 | 0.93 | SNCA (0.44) | SNCAHIF1ASCN4ATAAR1SLC6A2 | |
| Bromide SCHEMBL6060755 | 0.90 | SNCA (0.39) | SNCASCN4ATAAR1SLC6A2SIGMAR1 | |
| Iodide SCHEMBL6060968 | 0.86 | TAAR1 (0.39) | SNCASCN4ATAAR1SLC6A2SIGMAR1 | |
| Hydrochloric Acid SCHEMBL6060719 | 0.86 | TAAR1 (0.39) | SNCASCN4ATAAR1SLC6A2SIGMAR1 | |
| Hydrochloric Acid SCHEMBL28678048 | 0.84 | SNCA (0.41) | SNCAHIF1ASCN4ATAAR1SLC6A2 | |
| Bromide SCHEMBL163158 | 0.80 | SNCA (0.67) | SNCAHIF1ATAAR1SLC6A2SIGMAR1 | |
| Bromide SCHEMBL7197753 | 0.79 | SNCA (0.37) | SNCATAAR1CYP2A6CYP1A2LMNA | |
| Phosphoric Acid SCHEMBL7195799 | 0.79 | LAP3 (0.40) | L3MBTL1ALDH1A1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11319276-B2 | Preparation of diesters of (meth)acrylic acid from epoxides | EVONIK OPERATIONS GMBH (DE) | 2022-05-03 | — | — | US | disclosed |
| US-10676571-B2 | Polyetherimides with improved melt stability | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2020-06-09 | — | — | US | disclosed |
| EP-3652141-A1 | PREPARATION OF DIESTERS OF (METH)ACRYLIC ACID FROM EPOXIDES | Evonik Degussa GmbH (DE) | 2020-05-20 | — | — | EP | disclosed |
| WO-2020035561-A1 | PREPARATION OF DIESTERS OF (METH)ACRYLIC ACID FROM EPOXIDES | EVONIK OPERATIONS GMBH (DE) | 2020-02-20 | — | — | WO | disclosed |
| EP-2904032-B1 | METHODS OF MANUFACTURE OF BIS(PHTHALIMIDE)S AND POLYETHERIMIDES, AND BIS(PHTHALIMIDE)S, AND POLYETHERIMIDES FORMED THEREFROM | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2018-03-07 | — | — | EP | disclosed |
| EP-3077445-A1 | POLYETHERIMIDES WITH IMPROVED MELT STABILITY | SABIC Global Technologies B.V. (NL) | 2016-10-12 | — | — | EP | disclosed |
| WO-2016033156-A1 | IRON-CATALYZED OXIDATIVE POLYMERIZATION OF PHENOLS | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2016-03-03 | — | — | WO | disclosed |
| EP-2904032-A2 | METHODS OF MANUFACTURE OF BIS(PHTHALIMIDE)S AND POLYETHERIMIDES, AND BIS(PHTHALIMIDE)S, AND POLYETHERIMIDES FORMED THEREFROM | SABIC Global Technologies B.V. (NL) | 2015-08-12 | — | — | EP | disclosed |
| WO-2015084781-A1 | POLYETHERIMIDES WITH IMPROVED MELT STABILITY | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2015-06-11 | — | — | WO | disclosed |
| US-20150152224-A1 | POLYETHERIMIDES WITH IMPROVED MELT STABILITY | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2015-06-04 | — | — | US | disclosed |
| US-20140099510-A1 | METHODS OF MANUFACTURE OF BIS(PHTHALIMIDE)S AND POLYETHERIMIDES, AND BIS(PHTHALIMIDE)S, AND POLYETHERIMIDES FORMED THEREFROM | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2014-04-10 | — | — | US | disclosed |
| WO-2014055856-A2 | METHODS OF MANUFACTURE OF BIS(PHTHALIMIDE)S AND POLYETHERIMIDES, AND BIS(PHTHALIMIDE)S, AND POLYETHERIMIDES FORMED THEREFROM | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2014-04-10 | — | — | WO | disclosed |
| EP-1021426-A4 | CATALYTIC ASYMMETRIC EPOXIDATION | UNIV COLORADO STATE RES FOUND (US) | 2000-07-26 | — | — | EP | disclosed |
| EP-1021426-A1 | CATALYTIC ASYMMETRIC EPOXIDATION | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1998015544-A1 | CATALYTIC ASYMMETRIC EPOXIDATION | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0220810-A1 | Insecticidal ethers | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-05-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11319276-B2 | Preparation of diesters of (meth)acrylic acid from epoxides | MMAB, EPHX2, MTHFD2 | SNCA 4528/4885HIF1A 246/4885SCN4A 4555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.