Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8067073 | 0.86 | PDE4B (0.50) | PDE4BCHRM3PDE4DHDAC4HDAC2 | |
| SCHEMBL7918270 | 0.85 | PDE4B (0.44) | MEN1KMT2APDE4BPDE4DL3MBTL1 | |
| SCHEMBL8064986 | 0.85 | PDE4B (0.44) | MEN1KMT2APDE4BPDE4DL3MBTL1 | |
| SCHEMBL13578435 | 0.83 | POLB (0.46) | POLBMEN1KMT2APDE4BMAPT | |
| SCHEMBL8068535 | 0.82 | HDAC7 (0.49) | MEN1KMT2APDE4BCHRM3PDE4D | |
| SCHEMBL8066164 | 0.81 | PDE4B (0.44) | POLBMEN1KMT2APDE4BMAPT | |
| SCHEMBL8066233 | 0.81 | PDE4B (0.41) | POLBPDE4BMAPTPDE4DHDAC4 | |
| SCHEMBL8070006 | 0.81 | PDE4B (0.41) | POLBPDE4BMAPTPDE4DHDAC4 | |
| SCHEMBL3798699 | 0.80 | MEN1 (0.46) | POLBMEN1KMT2APDE4BMAPT | |
| SCHEMBL8071515 | 0.80 | HDAC7 (0.45) | KMT2APDE4BPDE4DHDAC4HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |