Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 7/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8068535 | 0.96 | HDAC7 (0.49) | HDAC7PDE4BKMT2AALDH1A1PDE4D | |
| SCHEMBL7918270 | 0.88 | PDE4B (0.44) | PDE4BKMT2APDE4DHCRTR1HCRTR2 | |
| SCHEMBL8064986 | 0.88 | PDE4B (0.44) | PDE4BKMT2APDE4DHCRTR1HCRTR2 | |
| SCHEMBL8066070 | 0.85 | HTT (0.57) | HDAC7KMT2AHTTHDAC4HDAC2 | |
| SCHEMBL15906095 | 0.84 | KMT2A (0.46) | HDAC7PDE4BKMT2AALDH1A1HCRTR1 | |
| SCHEMBL8066228 | 0.81 | HTT (0.48) | ALDH1A1HTT | |
| SCHEMBL8071983 | 0.80 | HCRTR2 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL8058230 | 0.80 | HCRTR2 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL8053373 | 0.80 | POLB (0.46) | PDE4BKMT2AALDH1A1PDE4DHDAC4 | |
| SCHEMBL3787880 | 0.80 | ALDH1A1 (0.43) | PDE4BKMT2AALDH1A1PDE4DHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |