SCHEMBL8053563

SCHEMBL8053563

Nc1c(F)c(F)cc(F)c1S

nearest known ligand 0.36

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CA1 P00915 3/20 0.36
CA2 P00918 3/20 0.36
CA12 O43570 1/20 0.36
CA7 P43166 1/20 0.36
CA13 Q8N1Q1 1/20 0.36
CA4 P22748 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL443790 0.97 CA1 (0.34) CA1CA2CA12CA7CA13
SCHEMBL461597 0.80 CA1 (0.43) CA1CA2CA12CA7CA13
SCHEMBL11821539 0.79 CA1 (0.36) CA1CA2CA12CA7CA13
SCHEMBL6522462 0.75 CA1 (0.35) CA1CA2CA12CA7CA13
Benzene SCHEMBL29240836 0.75 CA1 (0.40) CA1CA2CA12CA7CA13
SCHEMBL859273 0.75 CA1 (0.40) CA1CA2CA12CA7CA13
SCHEMBL48385 0.74 CA1 (0.38) CA1CA2CA12CA7CA13
SCHEMBL6512883 0.72 CA1 (0.33) CA1CA2CA12CA7CA13
SCHEMBL6512888 0.72 CA1 (0.33) CA1CA2CA12CA7CA13
SCHEMBL6522388 0.72 CA1 (0.33) CA1CA2CA12CA7CA13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0719767-B1 SUCCINAMIC ACID COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF SENJU PHARMA CO (JP) 2000-05-03 EP claimed
US-5688818-A ENZYME INHIBITORS SENJU PHARMACEUTICAL CO., LTD. (JP) 1997-11-18 US claimed
CN-1134699-A Succinamic acid compound, process for producing the same, and use thereof SENJU PHARMA CO (JP) 1996-10-30 CN claimed
EP-0719767-A1 SUCCINAMIC ACID COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF Senju Pharmaceutical Co., Ltd. (JP) 1996-07-03 EP claimed
JP-7082259-A None JP disclosed
US-20090163535-A1 Substituted Heteroarylalkanoic Acids THE INSTITUES FOR PHARMACEUTICAL DISCOVERY, INC. (US) 2009-06-25 US disclosed
US-7361671-B2 Substituted heteroarylalkanoic acids THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY, INC. (US) 2008-04-22 US disclosed
US-20070161631-A1 Substituted Phenoxyacetic Acids PHARMACIA & UPJOHN COMPANY 2007-07-12 US disclosed
US-7189749-B2 Substituted phenoxyacetic acids THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY LLC (US) 2007-03-13 US disclosed
EP-0719767-B1 SUCCINAMIC ACID COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF SENJU PHARMA CO (JP) 2000-05-03 EP disclosed
EP-0714893-B1 2-substituted benzothiazole derivatives useful in the treatment of diabetic complications GRELAN PHARMACEUTICAL CO (JP) 1998-10-21 EP disclosed
US-5700819-A ALDOSE REDUCTASE ENZYME INHIBITOR GRELAN PHARMACEUTICAL CO., LTD. (JP) 1997-12-23 US disclosed
US-5688818-A ENZYME INHIBITORS SENJU PHARMACEUTICAL CO., LTD. (JP) 1997-11-18 US disclosed
CN-1134699-A Succinamic acid compound, process for producing the same, and use thereof SENJU PHARMA CO (JP) 1996-10-30 CN disclosed
EP-0719767-A1 SUCCINAMIC ACID COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF Senju Pharmaceutical Co., Ltd. (JP) 1996-07-03 EP disclosed
EP-0714893-A1 2-substituted benzothiazole derivatives useful in the treatment of diabetic complications GRELAN PHARMACEUTICAL CO., LTD. (JP) 1996-06-05 EP disclosed
JP-H0782259-A SUCCINAMIC ACID DERIVATIVE AND MEDICINE CONTAINING THE SAME FOR THERAPY OF DIABETIC COMPLICATIONS SENJU PHARMACEUT CO LTD 1995-03-28 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090163535-A1 Substituted Heteroarylalkanoic Acids GPR119, LIPA, LIPC CA1 3818/4885CA2 1778/4885CA12 2990/4885
US-20070161631-A1 Substituted Phenoxyacetic Acids SLC5A2, GPR119, SLC5A1 CA1 2400/4885CA2 815/4885CA12 1519/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.