Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30884749 | 0.85 | KDM4E (0.57) | KDM4EALDH1A1HSD17B10ALOX15MEN1 | |
| SCHEMBL21450559 | 0.85 | KDM4E (0.57) | KDM4EALDH1A1HSD17B10ALOX15MEN1 | |
| SCHEMBL29084613 | 0.85 | KDM4E (0.57) | KDM4EALDH1A1HSD17B10ALOX15MEN1 | |
| SCHEMBL8961778 | 0.83 | KDM4E (0.55) | KDM4EALDH1A1HSD17B10ALOX15MEN1 | |
| SCHEMBL21450560 | 0.83 | KDM4E (0.81) | KDM4EALDH1A1HSD17B10ALOX15MEN1 | |
| SCHEMBL30884801 | 0.83 | KDM4E (0.81) | KDM4EALDH1A1HSD17B10ALOX15MEN1 | |
| SCHEMBL26915140 | 0.80 | HPGD (0.52) | KDM4EALDH1A1HSD17B10ALOX15MEN1 | |
| SCHEMBL30809587 | 0.80 | HPGD (0.52) | KDM4EALDH1A1HSD17B10ALOX15MEN1 | |
| SCHEMBL30343721 | 0.79 | MAPK1 (0.67) | KDM4EALDH1A1HSD17B10ALOX15KMT2A | |
| SCHEMBL19994519 | 0.79 | MAPK1 (0.67) | KDM4EALDH1A1HSD17B10ALOX15KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100273-A | TOPOISOMERASE INHIBITOR ANTITUMOR AGENT | GLAXO WELLCOME INC. (US) | 2000-08-08 | — | — | US | disclosed |
| US-5559235-A | ANTITUMOR | GLAXO WELLCOME INC. (US) | 1996-09-24 | — | — | US | disclosed |
| EP-0540099-B1 | Water soluble camptothecin derivatives | GLAXO WELLCOME INC (US) | 1996-04-17 | — | — | EP | disclosed |
| EP-0673380-A1 | WATER SOLUBLE CAMPTOTHECIN DERIVATIVES | GLAXO WELLCOME INC. (US) | 1995-09-27 | — | — | EP | disclosed |
| US-5342947-A | Treating alkylenedioxy-7-trihaloacetamidomethylenecamptothecin with hydrochloric or sulfuric acid to yield amine salt, treating with alkali metal hydroxide or carbonate to obtain free base | GLAXO INC. (US) | 1994-08-30 | — | — | US | disclosed |
| WO-1994011377-A2 | WATER SOLUBLE CAMPTOTHECIN DERIVATIVES | GLAXO INC. (US) | 1994-05-26 | — | — | WO | disclosed |
| EP-0540099-A1 | Water soluble camptothecin derivatives | GLAXO WELLCOME INC. (US) | 1993-05-05 | — | — | EP | disclosed |