Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8053708 | 0.83 | KDM4E (0.57) | KDM4EALDH1A1HSD17B10ALOX15MEN1 | |
| SCHEMBL21450559 | 0.83 | KDM4E (0.57) | KDM4EALDH1A1HSD17B10ALOX15MEN1 | |
| SCHEMBL30884749 | 0.83 | KDM4E (0.57) | KDM4EALDH1A1HSD17B10ALOX15MEN1 | |
| SCHEMBL29084613 | 0.83 | KDM4E (0.57) | KDM4EALDH1A1HSD17B10ALOX15MEN1 | |
| SCHEMBL21450560 | 0.81 | KDM4E (0.81) | KDM4EALDH1A1HSD17B10ALOX15MEN1 | |
| SCHEMBL30884801 | 0.81 | KDM4E (0.81) | KDM4EALDH1A1HSD17B10ALOX15MEN1 | |
| SCHEMBL8961789 | 0.77 | ALDH1A1 (0.45) | KDM4EALDH1A1HSD17B10MEN1POLB | |
| SCHEMBL30809452 | 0.76 | KDM4E (0.52) | KDM4EALDH1A1HSD17B10ALOX15MEN1 | |
| SCHEMBL26915206 | 0.76 | KDM4E (0.52) | KDM4EALDH1A1HSD17B10ALOX15MEN1 | |
| SCHEMBL31536518 | 0.76 | KDM4E (0.52) | KDM4EALDH1A1HSD17B10ALOX15MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559235-A | ANTITUMOR | GLAXO WELLCOME INC. (US) | 1996-09-24 | — | — | US | disclosed |
| EP-0540099-B1 | Water soluble camptothecin derivatives | GLAXO WELLCOME INC (US) | 1996-04-17 | — | — | EP | disclosed |
| US-5342947-A | Treating alkylenedioxy-7-trihaloacetamidomethylenecamptothecin with hydrochloric or sulfuric acid to yield amine salt, treating with alkali metal hydroxide or carbonate to obtain free base | GLAXO INC. (US) | 1994-08-30 | — | — | US | disclosed |
| EP-0540099-A1 | Water soluble camptothecin derivatives | GLAXO WELLCOME INC. (US) | 1993-05-05 | — | — | EP | disclosed |