Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL805453 | 0.92 | HDAC4 (0.40) | ESR1HDAC4SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL15043623 | 0.81 | ESR1 (0.44) | ESR1HDAC4SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL4013884 | 0.81 | SLC6A3 (0.60) | ESR1HDAC4SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL14893972 | 0.81 | HDAC4 (0.45) | ESR1HDAC4SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL9004269 | 0.80 | HDAC4 (0.46) | ESR1HDAC4SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL15043621 | 0.80 | SLC6A3 (0.44) | ESR1HDAC4SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL19831806 | 0.78 | PSEN1 (0.40) | SLC6A3SLC6A4SLC6A2KDM1APSEN1 | |
| SCHEMBL23251457 | 0.78 | BACE1 (0.40) | HDAC4SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL805456 | 0.77 | GRIN1 (0.51) | HDAC4SLC6A3SLC6A4SLC6A2KDM1A | |
| SCHEMBL7251147 | 0.77 | ESR1 (0.43) | ESR1HDAC4SLC6A3SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071461-A1 | Substituted Benzamide Compounds | GRUENENTHAL GMBH (DE) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071461-A1 | Substituted Benzamide Compounds | BDKRB1, BDKRB2, HRH2 | ESR1 1350/4885HDAC4 2231/4885SLC6A3 1597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.