SCHEMBL8054975

SCHEMBL8054975

Cc1c(CCC(=O)ON2C(=O)CCC2=O)c(=O)oc2cc(N)ccc12

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PSMB8 P28062 2/20 0.62
PSMB5 P28074 1/20 0.62
SRC P12931 1/20 0.56
KDM4E B2RXH2 8/20 0.53
ALDH1A1 P00352 8/20 0.53
HPGD P15428 7/20 0.53
HSD17B10 Q99714 6/20 0.53
GAA P10253 3/20 0.53
GLA P06280 2/20 0.53
CASP1 P29466 2/20 0.53
CASP7 P55210 2/20 0.53
TSHR P16473 2/20 0.49
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
PKM P14618 1/20 0.45
HSD17B3 P37058 1/20 0.44
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
CTDSP1 Q9GZU7 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2528490 0.90 SRC (0.53) PSMB8PSMB5SRCKDM4EALDH1A1
SCHEMBL29577443 0.90 SRC (0.53) PSMB8PSMB5SRCKDM4EALDH1A1
SCHEMBL7024344 0.88 KDM4E (0.69) PSMB8PSMB5KDM4EALDH1A1HPGD
SCHEMBL1264617 0.83 SRC (0.46) PSMB8PSMB5SRCKDM4EMEN1
SCHEMBL8352874 0.82 PSMB8 (0.59) PSMB8PSMB5KDM4EALDH1A1HPGD
SCHEMBL19465287 0.82 SRC (0.46) PSMB8PSMB5SRCKDM4EALDH1A1
SCHEMBL13567282 0.80 PSMB8 (0.45) PSMB8PSMB5SRCKDM4EALDH1A1
SCHEMBL7576024 0.80 KDM4E (0.74) PSMB8SRCKDM4EALDH1A1HPGD
SCHEMBL593432 0.78 KDM4E (0.57) PSMB8PSMB5KDM4EALDH1A1HPGD
SCHEMBL29385493 0.78 KDM4E (0.57) PSMB8PSMB5KDM4EALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0660935-B1 IMMUNOLOGICAL DETECTION USING TWO DETECTABLE LABELS MARCONI GEC LTD (GB) 2000-05-24 EP disclosed
US-5723304-A Immunological detection using two detectable labels GEC-MARCONI LIMITED (GB) 1998-03-03 US disclosed
EP-0660935-A1 IMMUNOLOGICAL DETECTION USING TWO DETECTABLE LABELS GEC-MARCONI LIMITED (GB) 1995-07-05 EP disclosed
WO-1994003811-A1 IMMUNOLOGICAL DETECTION USING TWO DETECTABLE LABELS GEC-MARCONI LIMITED (GB) 1994-02-17 WO disclosed