Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL659152 | 0.80 | HTT (0.40) | HTTAPPRAB9AALDH1A1KMT2A | |
| SCHEMBL8052248 | 0.79 | NQO2 (0.47) | HTTKDM4ERAB9AALDH1A1KMT2A | |
| SCHEMBL4857995 | 0.75 | APP (0.50) | HTTAPPACHEKDM4ERAB9A | |
| SCHEMBL3887904 | 0.71 | RAB9A (0.58) | HTTAPPKDM4ERAB9AALDH1A1 | |
| SCHEMBL9305472 | 0.71 | APP (0.46) | APPACHEKDM4ERAB9AALDH1A1 | |
| SCHEMBL74889 | 0.71 | PDPK1 (0.53) | HTTAPPACHERAB9AALDH1A1 | |
| SCHEMBL9305900 | 0.71 | APP (0.46) | APPACHEKDM4ERAB9AALDH1A1 | |
| SCHEMBL8054536 | 0.70 | TLR8 (0.46) | HTTAPPACHEKDM4ERAB9A | |
| SCHEMBL8051929 | 0.70 | TLR8 (0.46) | HTTAPPACHEKDM4ERAB9A | |
| Hydrochloric Acid SCHEMBL28519023 | 0.69 | RAB9A (0.57) | HTTAPPKDM4ERAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130217-A | ANTITUMOR | PFIZER INC (US) | 2000-10-10 | — | — | US | disclosed |
| WO-1994022846-A1 | COMPOUNDS ENHANCING ANTITUMOR ACTIVITY OF OTHER CYTOTOXIC AGENTS | PFIZER INC. (US) | 1994-10-13 | — | — | WO | disclosed |