Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GRN | P28799 | 2/20 | 0.39 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL727 | 0.88 | POLB (0.51) | POLBKDM4EGRNSORT1ALDH1A1 | |
| SCHEMBL8067023 | 0.86 | GRN (0.38) | POLBKDM4EGRNSORT1CA12 | |
| SCHEMBL2934234 | 0.79 | KDM4E (0.47) | POLBKDM4EGRNSORT1ALDH1A1 | |
| SCHEMBL1017 | 0.78 | GRN (0.43) | POLBKDM4EGRNSORT1ALDH1A1 | |
| SCHEMBL17288712 | 0.77 | KDM4E (0.46) | POLBKDM4EGRNSORT1HCAR2 | |
| SCHEMBL28251767 | 0.77 | ALDH1A1 (0.41) | POLBKDM4EGRNSORT1ALDH1A1 | |
| SCHEMBL20503261 | 0.76 | KDM4E (0.45) | POLBKDM4EGRNSORT1HCAR2 | |
| SCHEMBL13742833 | 0.76 | GRN (0.45) | POLBKDM4EGRNSORT1GAA | |
| SCHEMBL8056297 | 0.75 | GRN (0.47) | POLBKDM4EGRNSORT1GAA | |
| SCHEMBL13995818 | 0.75 | POLB (0.51) | POLBKDM4EGRNSORT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270425-A1 | 3-(DIHYDRO-1H-PYRAZOLO[4,3-D]PYRIMIDIN-5-YL)-4-PROPOXYBENZENESULFONAMIDE DERIVATIVES AND METHODS OF USE | CONCERT PHARMACEUTICALS INC. (US) | 2009-10-29 | — | — | US | disclosed |
| US-20090197899-A1 | 3-(Dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxybenzenesulfonamide Derivatives and Methods of Use | CONCERT PHARMACEUTICALS INC. (US) | 2009-08-06 | — | — | US | disclosed |
| US-20090062298-A1 | DEUTERIUM-ENRICHED SILDENAFIL | PROTIA, LLC (US) | 2009-03-05 | — | — | US | disclosed |
| US-20080194529-A1 | HIGHLY SELECTIVE and LONG-ACTING PDE5 MODULATORS | AUSPEX PHARMACEUTICALS, INC. (US) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270425-A1 | 3-(DIHYDRO-1H-PYRAZOLO[4,3-D]PYRIMIDIN-5-YL)-4-PROPOXYBENZENESULFONAMIDE DERIVATIVES AND METHODS OF USE | PDE5A, PDE3A, PDE3B | POLB 700/4885KDM4E 835/4885GRN 2653/4885 |
| US-20090062298-A1 | DEUTERIUM-ENRICHED SILDENAFIL | PDE5A, PDE3A, PDE2A | POLB 1533/4885KDM4E 720/4885GRN 2829/4885 |
| US-20090197899-A1 | 3-(Dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxybenzenesulfonamide Derivatives and Methods of Use | PDE5A, PDE3A, PDE3B | POLB 700/4885KDM4E 835/4885GRN 2653/4885 |
| US-20080194529-A1 | HIGHLY SELECTIVE and LONG-ACTING PDE5 MODULATORS | PDE5A, PDE7A, PDE3A | POLB 1336/4885KDM4E 939/4885GRN 4396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.