Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | GRN | P28799 | 2/20 | 0.50 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2934234 | 0.90 | KDM4E (0.47) | POLBKDM4EGRNSORT1GAA | |
| SCHEMBL8055438 | 0.88 | POLB (0.42) | POLBKDM4EGRNSORT1GAA | |
| SCHEMBL17288712 | 0.88 | KDM4E (0.46) | POLBKDM4EGRNSORT1CA12 | |
| SCHEMBL20503261 | 0.87 | KDM4E (0.45) | POLBKDM4EGRNSORT1HCAR2 | |
| SCHEMBL13995818 | 0.86 | POLB (0.51) | POLBKDM4EGRNSORT1GAA | |
| SCHEMBL343503 | 0.85 | GRN (0.53) | POLBKDM4EGRNSORT1CA12 | |
| SCHEMBL3055278 | 0.84 | POLB (0.50) | POLBKDM4EGRNSORT1GAA | |
| SCHEMBL13485372 | 0.84 | POLB (0.50) | POLBKDM4EGAAGFERMAPK1 | |
| Hydrochloric Acid SCHEMBL6378087 | 0.84 | GRN (0.51) | POLBKDM4EGRNSORT1CA12 | |
| SCHEMBL8508457 | 0.83 | GRN (0.55) | POLBKDM4EGRNSORT1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115536587-B | Method for preparing sildenafil intermediate by micro-channel nitration | 衡阳小桔制药有限公司 | 2025-03-04 | — | — | CN | claimed |
| CN-115536587-A | Method for preparing sildenafil intermediate by micro-channel nitration | 衡阳小桔制药有限公司 | 2022-12-30 | — | — | CN | claimed |
| EP-3099689-B1 | PYRAZOLOPYRIMIDINONES FOR THE TREATMENT OF IMPOTENCE AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2022-01-26 | — | — | EP | claimed |
| CN-109721538-A | A kind of novel synthesis of 1- methyl -3- propylpyrazol -5- carboxylic acid | 孙双 | 2019-05-07 | — | — | CN | claimed |
| US-10017511-B2 | Pyrazolopyrimidinones for the treatment of impotence and process for the preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2018-07-10 | — | — | US | claimed |
| US-20170066771-A1 | Pyrazolopyrimidinones for the treatment of impotence and process for the preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-03-09 | — | — | US | claimed |
| EP-3099689-A1 | PYRAZOLOPYRIMIDINONES FOR THE TREATMENT OF IMPOTENCE AND PROCESS FOR THE PREPARATION THEREOF | Council of Scientific and Industrial Research (IN) | 2016-12-07 | — | — | EP | claimed |
| CN-105622512-A | Nitration synthesis process applicable to industrial sildenafil midbody | JINLIN MEDICAL COLLEGE | 2016-06-01 | — | — | CN | claimed |
| WO-2015114647-A1 | PYRAZOLOPYRIMIDINONES FOR THE TREATMENT OF IMPOTENCE AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2015-08-06 | — | — | WO | claimed |
| US-6960661-B2 | [7-(3-chloro-4-methoxybenzlamino)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-ylmethoxy]acetic acid, synthesis thereof and intermediates used therein | MERCK PATENT GMBH (DE) | 2005-11-01 | — | — | US | claimed |
| US-20040053945-A1 | Process for the preparation of a pyrazolo[4,3-d]pyrimidine derivative | MERCK PATENT GMBH (DE) | 2004-03-18 | — | — | US | claimed |
| EP-1358189-A1 | PROCESS FOR THE PREPARATION OF A PYRAZOLO 4,3-D]PYRIMIDINE DERIVATIVE | MERCK PATENT GmbH (DE) | 2003-11-05 | — | — | EP | claimed |
| WO-2002059126-A1 | PROCESS FOR THE PREPARATION OF A PYRAZOLO[4,3-D]PYRIMIDINE DERIVATIVE | MERCK PATENT GMBH (DE) | 2002-08-01 | — | — | WO | claimed |
| WO-2025049827-A1 | FRAGRANCE AND FLAVOR COMPOSITIONS COMPRISING PYRAZOLE DERIVATIVES | OSMO LABS, PBC (US) | 2025-03-06 | — | — | WO | disclosed |
| CN-115536587-B | Method for preparing sildenafil intermediate by micro-channel nitration | 衡阳小桔制药有限公司 | 2025-03-04 | — | — | CN | disclosed |
| CN-115536587-B | Method for preparing sildenafil intermediate by micro-channel nitration | 衡阳小桔制药有限公司 | 2025-03-04 | — | — | CN | disclosed |
| EP-0526004-A1 | Pyrazolopyrimidinone antianginal agents | Pfizer Limited (GB) | 1993-02-03 | — | — | EP | disclosed |
| CN-1068329-A | Pyrazolopyrimidinoneantianginal antianginal agents | PFIZER (US) | 1993-01-27 | — | — | CN | disclosed |
| EP-0463756-A1 | Pyrazolopyrimidinone antianginal agents | Pfizer Limited (GB) | 1992-01-02 | — | — | EP | disclosed |
| CN-1057464-A | Pyrazolopyrimidinoneantianginal antianginal agents | PFIZER (US) | 1992-01-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10017511-B2 | Pyrazolopyrimidinones for the treatment of impotence and process for the preparation thereof | PDE5A, PDE3A, PDE3B | POLB 2408/4885KDM4E 170/4885GRN 4204/4885 |
| US-20170066771-A1 | Pyrazolopyrimidinones for the treatment of impotence and process for the preparation thereof | PDE5A, PDE3A, PDE3B | POLB 2408/4885KDM4E 170/4885GRN 4204/4885 |
| US-20040053945-A1 | Process for the preparation of a pyrazolo[4,3-d]pyrimidine derivative | HPD, DDC, KMO | POLB 607/4885KDM4E 591/4885GRN 3179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.