Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | S100A4 | P26447 | 3/20 | 0.43 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.42 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | MAOA | P21397 | 5/20 | 0.41 |
| ▸ | PTPRC | P08575 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3702862 | 0.82 | ALDH1A1 (0.45) | ADORA2AMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL22233095 | 0.77 | ADORA2A (0.53) | ADORA2AMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL308115 | 0.74 | ADORA2A (0.76) | ADORA2AMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL7469082 | 0.73 | MAPT (0.53) | MEN1KMT2AALDH1A1TDP1S100A4 | |
| SCHEMBL8764869 | 0.73 | ALDH1A1 (0.47) | ADORA2AMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL19299392 | 0.73 | DNMT1 (0.50) | ADORA2AMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL8671883 | 0.72 | ADORA2A (0.57) | ADORA2AMEN1KMT2AALDH1A1S100A4 | |
| SCHEMBL1532068 | 0.71 | MAPT (0.62) | MEN1KMT2AALDH1A1TDP1MAPT | |
| SCHEMBL19299398 | 0.71 | PTPRC (0.55) | ADORA2AMEN1KMT2AALDH1A1S100A4 | |
| SCHEMBL583089 | 0.69 | ADORA2A (0.53) | ADORA2AMEN1KMT2AALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817767-B1 | BICYCLIC AMINE DERIVATIVES AND THEIR USE AS ANTI-PSYCHOTIC AGENTS | SMITHKLINE BEECHAM PLC (GB) | 2000-05-24 | — | — | EP | disclosed |
| US-6008219-A | Bicyclic amine derivatives and their use as anti-psychotic agents | SMITHKLINE BEECH P.L.C. (GB) | 1999-12-28 | — | — | US | disclosed |
| EP-0817767-A1 | BICYCLIC AMINE DERIVATIVES AND THEIR USE AS ANTI-PSYCHOTIC AGENTS | SMITHKLINE BEECHAM PLC (GB) | 1998-01-14 | — | — | EP | disclosed |
| WO-1996030333-A1 | BICYCLIC AMINE DERIVATIVES AND THEIR USE AS ANTI-PSYCHOTIC AGENTS | SMITHKLINE BEECHAM PLC (GB) | 1996-10-03 | — | — | WO | disclosed |