SCHEMBL8055980

SCHEMBL8055980

COC(=O)c1ccc(C(O)c2cccnc2)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.59
SMN1; SMN2 Q16637 3/20 0.58
CYP17A1 P05093 1/20 0.54
CA12 O43570 1/20 0.50
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
CA9 Q16790 1/20 0.50
CA14 Q9ULX7 1/20 0.50
SLC2A1 P11166 1/20 0.49
CYP19A1 P11511 1/20 0.49
CYP11B1 P15538 1/20 0.49
CYP11B2 P19099 1/20 0.49
LMNA P02545 2/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
KMT2A Q03164 3/20 0.47
GAA P10253 1/20 0.47
MAPT P10636 1/20 0.45
MEN1 O00255 1/20 0.45
NPC1 O15118 1/20 0.45
RAB9A P51151 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10687604 0.87 CYP19A1 (0.62) ALDH1A1SMN1; SMN2CYP17A1SLC2A1CYP19A1
SCHEMBL27707350 0.83 ALDH1A1 (0.56) ALDH1A1SMN1; SMN2SLC2A1CYP19A1CYP11B1
SCHEMBL866718 0.82 TSHR (0.64) ALDH1A1SMN1; SMN2CA12CA1CA2
SCHEMBL30251598 0.82 TSHR (0.64) ALDH1A1SMN1; SMN2CA12CA1CA2
SCHEMBL4408604 0.82 CA1 (0.66) ALDH1A1CA12CA1CA2CA9
SCHEMBL1507916 0.79 SMN1; SMN2 (0.54) ALDH1A1SMN1; SMN2CYP17A1LMNAL3MBTL1
SCHEMBL9211456 0.79 ALDH1A1 (0.55) ALDH1A1SMN1; SMN2SLC2A1LMNAL3MBTL1
SCHEMBL9311555 0.78 SMN1; SMN2 (0.66) SMN1; SMN2CYP17A1CYP19A1CYP11B1LMNA
SCHEMBL10966183 0.78 SMN1; SMN2 (0.66) SMN1; SMN2CYP17A1LMNAL3MBTL1KMT2A
SCHEMBL7475779 0.78 ATM (0.58) ALDH1A1CA12CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6114534-A REACTING A KETONE DERIVATIVE OF CARBAMOYL SUBSTITUTED HETEROCYCLE WITH PHOSPHORANE, FOLLOWED BY ACIDIFICATION TO FORM AN ANTICOAGULANT ELI LILLY AND COMPANY (US) 2000-09-05 US disclosed
US-6075147-A OMEGA-PHENYL-OMEGA-(3-PYRIDYL)-OMEGA-ALKENOIC ACID DERIVATIVES BEARING A CARBAMOYL SUBSTITUTED OXAZOLYL OR OXAZOLINYL GROUP ON THE PHENYL RING IS USEFUL FOR THROMBOXANE RECEPTOR ANTAGONSIM OR THROMBOXANE SYNTHASE INHIBITOR ELI LILLY AND COMPANY (US) 2000-06-13 US disclosed
US-6031095-A Intermediates in the preparation of substituted alkenoic acids ELI LILLY AND COMPANY (US) 2000-02-29 US disclosed
US-5990308-A Intermediates in the preparation of substituted alkenoic acids ELI LILLY AND COMPANY (US) 1999-11-23 US disclosed
US-5849766-A Carbamoyl substituted heterocycles ELI LILLY AND COMPANY (US) 1998-12-15 US disclosed
US-5849922-A Preparation of substituted alkenoic acids ELI LILLY AND COMPANY (US) 1998-12-15 US disclosed
EP-0816361-A2 Preparation of substituted alkenoic acids ELI LILLY AND COMPANY (US) 1998-01-07 EP disclosed
EP-0811621-A2 Carbamoyl substituted oxazoles as thromboxane receptor antagonists ELI LILLY AND COMPANY (US) 1997-12-10 EP disclosed
EP-0110996-A1 IMIDAZOLE DERIVATIVES Yoshitomi Pharmaceutical Industries, Ltd. (JP) 1984-06-20 EP disclosed