Sugi Predict

Sugi Predict / Compounds / SCHEMBL866718

SCHEMBL866718

SCHEMBL866718

COC(=O)c1ccc(C(O)c2ccccc2)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 1/20 0.64
▸ CA1 P00915 5/20 0.59
▸ CA2 P00918 5/20 0.59
▸ CA12 O43570 2/20 0.59
▸ CA9 Q16790 2/20 0.59
▸ CA14 Q9ULX7 2/20 0.59
▸ L3MBTL1 Q9Y468 3/20 0.58
▸ ALDH1A1 P00352 2/20 0.58
▸ GAA P10253 1/20 0.58
▸ OPRD1 P41143 2/20 0.56
▸ RAB9A P51151 4/20 0.56
▸ MAPT P10636 3/20 0.56
▸ CASP3 P42574 1/20 0.56
▸ SENP8 Q96LD8 1/20 0.56
▸ SENP7 Q9BQF6 1/20 0.56
▸ SENP6 Q9GZR1 1/20 0.56
▸ ROCK2 O75116 1/20 0.54
▸ SRD5A2 P31213 1/20 0.53
▸ TDP1 Q9NUW8 1/20 0.52
▸ CA7 P43166 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30251598 1.00 TSHR (0.64) TSHRCA1CA2CA12CA9
SCHEMBL4408604 0.92 CA1 (0.66) TSHRCA1CA2CA12CA9
SCHEMBL13266934 0.85 TSHR (0.64) TSHRCA1CA2CA12CA9
SCHEMBL2680771 0.85 TSHR (0.64) TSHRCA1CA2CA12CA9
SCHEMBL3340488 0.84 TSHR (0.58) TSHRCA1CA2CA9L3MBTL1
SCHEMBL9149153 0.84 TDP1 (0.51) TSHRCA1CA2CA12CA9
SCHEMBL3297654 0.84 CA1 (0.57) TSHRCA1CA2CA12CA9
SCHEMBL4248683 0.84 CA1 (0.61) TSHRCA1CA2CA12CA9
SCHEMBL16562046 0.84 TSHR (0.62) TSHRCA1CA2CA12CA9
SCHEMBL1765758 0.84 CA1 (0.57) TSHRCA1CA2CA12CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113387799-B Preparation method of gamma, gamma-diaryl ester or gamma, gamma-triaryl ester compound and product thereof 南京工业大学 2021-12-21 — — CN claimed
CN-113387799-A Preparation method of gamma, gamma-diaryl ester or gamma, gamma-triaryl ester compound and product thereof 南京工业大学 2021-09-14 — — CN claimed
EP-4126835-B1 INHIBITORS OF ANTIGEN PRESENTATION BY HLA-DR JANSSEN PHARMACEUTICA NV (BE) 2026-02-18 — — EP disclosed
US-12516038-B2 Inhibitors of antigen presentation by HLA-DR JANSSEN PHARMACEUTICA NV (BE) 2026-01-06 — — US disclosed
US-20230150985-A1 INHIBITORS OF ANTIGEN PRESENTATION BY HLA-DR JANSSEN PHARMACEUTICA NV (BE) 2023-05-18 — — US disclosed
EP-4126835-A1 INHIBITORS OF ANTIGEN PRESENTATION BY HLA-DR Janssen Pharmaceutica NV (BE) 2023-02-08 — — EP disclosed
CN-113387799-B Preparation method of gamma, gamma-diaryl ester or gamma, gamma-triaryl ester compound and product thereof 南京工业大学 2021-12-21 — — CN disclosed
WO-2021198283-A1 INHIBITORS OF ANTIGEN PRESENTATION BY HLA-DR JANSSEN PHARMACEUTICA NV (BE) 2021-10-07 — — WO disclosed
CN-113387799-A Preparation method of gamma, gamma-diaryl ester or gamma, gamma-triaryl ester compound and product thereof 南京工业大学 2021-09-14 — — CN disclosed
WO-2021093556-A1 METHOD FOR PREPARING HYDROXYL COMPOUND, DEUTERATED COMPOUND THEREOF, AND TRITIATED COMPOUND THEREOF 中国科学院福建物质结构研究所 2021-05-20 — — WO disclosed
CN-102442974-B Camphor derivative compound, and production method and use thereof WANG BINGJUN 2014-07-23 — — CN disclosed
US-6514985-B1 Induce the biosynthesis of cytokines such as interferon and tumor necrosis factor; exhibit antiviral and antitumor properties 3M INNOVATIVE PROPERTIES COMPANY 2003-02-04 — — US disclosed
US-20020173653-A1 Imidazonaphthyridines 3M INNOVATIVE PROPERTIES COMPANY 2002-11-21 — — US disclosed
US-20020173654-A1 Imidazonaphthyridines 3M INNOVATIVE PROPERTIES COMPANY 2002-11-21 — — US disclosed
US-6194425-B1 VIRICIDES, ANTITUMOR AGENTS 3M INNOVATIVE PROPERTIES COMPANY 2001-02-27 — — US disclosed
CN-1284957-A Imidazonaphthyridines and their use in inducing cytokine biosynthesis MINNESOTA MINING & MFG (US) 2001-02-21 — — CN disclosed
EP-1040112-A1 IMIDAZONAPHTHYRIDINES AND THEIR USE IN INDUCING CYTOKINE BIOSYNTHESIS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 2000-10-04 — — EP disclosed
US-6069149-A ANTIALLERGENS, ANTIINFLAMMATORY AGENTS TERUMO KABUSHIKI KAISHA (JP) 2000-05-30 — — US disclosed
WO-1999029693-A1 IMIDAZONAPHTHYRIDINES AND THEIR USE IN INDUCING CYTOKINE BIOSYNTHESIS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1999-06-17 — — WO disclosed
EP-0894797-A1 NOVEL AMIDE DERIVATIVES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF TERUMO KABUSHIKI KAISHA (JP) 1999-02-03 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230150985-A1 INHIBITORS OF ANTIGEN PRESENTATION BY HLA-DR HLA-DRB1, CD74, HLA-C TSHR 4709/4885CA1 3460/4885CA2 4223/4885
US-20020173653-A1 Imidazonaphthyridines IFNG, IRF3, IFNAR1 TSHR 1376/4885CA1 4235/4885CA2 4467/4885
US-20020173654-A1 Imidazonaphthyridines IFNG, IRF3, IFNAR1 TSHR 1376/4885CA1 4235/4885CA2 4467/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.