Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 11/20 | 0.48 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | ILK | Q13418 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8038827 | 0.98 | TLR8 (0.47) | TLR8TLR7CYP2D6CYP2C19NUDT1 | |
| SCHEMBL8053396 | 0.95 | TLR8 (0.46) | TLR8TLR7CYP2D6CYP2C19NUDT1 | |
| Hydrochloric Acid SCHEMBL8038529 | 0.93 | TLR8 (0.44) | TLR8TLR7CYP2D6CYP2C19NUDT1 | |
| SCHEMBL872125 | 0.88 | CYP2D6 (0.49) | TLR8TLR7CYP2D6CYP2C19CHUK | |
| Hydrochloric Acid SCHEMBL8038579 | 0.86 | CYP2D6 (0.47) | TLR8TLR7CYP2D6CYP2C19CHUK | |
| SCHEMBL8695685 | 0.81 | TLR8 (0.64) | TLR8TLR7 | |
| SCHEMBL20429891 | 0.78 | PLAU (0.41) | TLR8TLR7CHUK | |
| SCHEMBL10338024 | 0.75 | RAB9A (0.57) | NUDT1PDE5ACHUK | |
| SCHEMBL2510236 | 0.75 | KDM4E (0.41) | TLR8TLR7CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL9765063 | 0.74 | RAB9A (0.56) | NUDT1PDE5ACHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080750-A | FOR PROPHYLAXIS AND TREATMENT OF DISEASES CAUSED BY INFECTION BY ROTAVIRUS | NIPPON SHOJI KAISHA LTD. (JP) | 2000-06-27 | — | — | US | disclosed |
| EP-0806418-A2 | Novel pyrimidine compound and anti-rotavirus agent | NIPPON SHOJI KAISHA, LIMITED (JP) | 1997-11-12 | — | — | EP | disclosed |