Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.42 |
| ▸ | HTR2B | P41595 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.40 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8058146 | 0.88 | SLC9A1 (0.44) | HTR7HTR2BDRD2ADRA1DHTR2A | |
| SCHEMBL8060627 | 0.88 | HTR7 (0.43) | HTR7HTR2BDRD2ADRA1DHTR2A | |
| SCHEMBL8060649 | 0.85 | HTR7 (0.40) | HTR7HTR2BDRD2ADRA1DHTR2A | |
| SCHEMBL8056279 | 0.84 | HTR7 (0.40) | HTR7HTR2BDRD2ADRA1DHTR2A | |
| SCHEMBL8045152 | 0.83 | HTR7 (0.39) | HTR7HTR2BDRD2ADRA1DHTR2A | |
| SCHEMBL8045175 | 0.81 | HTR7 (0.44) | HTR7HTR2BDRD2ADRA1DHTR2A | |
| SCHEMBL8058029 | 0.80 | PDK2 (0.42) | — | |
| SCHEMBL8058179 | 0.80 | HTR2B (0.43) | HTR7HTR2BDRD2ADRA1DHTR2A | |
| SCHEMBL8062881 | 0.78 | HTR2B (0.44) | HTR7HTR2BDRD2ADRA1DHTR2A | |
| SCHEMBL8056953 | 0.77 | SLC9A1 (0.39) | HTR7HTR2BDRD2ADRA1DHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6028069-A | Heterocyclyl-condensed benzoylguanidines, their production and use as inhibitors of the cellular Na+/H+-antiporter | MERCK PATENT GESELLSCHAFT MIT BERSCHRANKER HAFTUNG (DE) | 2000-02-22 | — | — | US | disclosed |