Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.50 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.50 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TPMT | P51580 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL8375393 | 0.83 | HSD17B10 (0.46) | HSD17B10AKR1C3AKR1C2AKR1C1AKR1C4 | |
| SCHEMBL8372308 | 0.81 | HSD17B10 (0.59) | HSD17B10AKR1C3AKR1C2AKR1C1AKR1C4 | |
| SCHEMBL7813490 | 0.80 | HSD17B10 (1.00) | HSD17B10AKR1C3AKR1C2AKR1C1AKR1C4 | |
| SCHEMBL4318333 | 0.77 | HSD17B10 (0.69) | HSD17B10AKR1C3AKR1C2AKR1C1AKR1C4 | |
| SCHEMBL8541393 | 0.76 | HSD17B10 (0.67) | HSD17B10AKR1C3AKR1C2AKR1C1AKR1C4 | |
| SCHEMBL5672900 | 0.73 | AKR1C3 (0.55) | HSD17B10AKR1C3AKR1C2AKR1C1AKR1C4 | |
| SCHEMBL8375398 | 0.72 | HSD17B10 (0.62) | HSD17B10AKR1C3AKR1C2AKR1C1AKR1C4 | |
| SCHEMBL2226763 | 0.70 | AKR1C3 (0.61) | HSD17B10AKR1C3AKR1C2AKR1C1AKR1C4 | |
| SCHEMBL8955994 | 0.69 | KDM4E (0.49) | HSD17B10LCKKDM4ETPMTMYC | |
| SCHEMBL8044565 | 0.69 | HSD17B10 (0.57) | HSD17B10AKR1C3AKR1C2AKR1C1AKR1C4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0785920-B1 | MULTIFUNCTIONAL CROSS-LINKING REAGENTS FOR HEMOGLOBIN, AND CROSS-LINKED HEMOGLOBIN CONJUGATES | KLUGER RONALD (CA) | 2000-05-17 | — | — | EP | disclosed |
| EP-0669940-B1 | SPECIFICALLY CROSSLINKED HEMOGLOBIN WITH FREE FUNCTIONALITY | UNIV TORONTO (CA) | 1999-02-10 | — | — | EP | disclosed |
| US-5811521-A | Multifunctional crosslinking reagents for hemoglobin, and crosslinked hemoglobin conjugates | KLUGER RONALD H (CA) | 1998-09-22 | — | — | US | disclosed |
| EP-0785920-A1 | MULTIFUNCTIONAL CROSS-LINKING REAGENTS FOR HEMOGLOBIN, AND CROSS-LINKED HEMOGLOBIN CONJUGATES | KLUGER, Ronald (CA) | 1997-07-30 | — | — | EP | disclosed |
| WO-1997000236-A1 | MULTIFUNCTIONAL CROSS-LINKING REAGENTS FOR HEMOGLOBIN, AND CROSS-LINKED HEMOGLOBIN CONJUGATES | KLUGER RONALD (CA) | 1997-01-03 | — | — | WO | disclosed |
| EP-0669940-A1 | SPECIFICALLY CROSSLINKED HEMOGLOBIN WITH FREE FUNCTIONALITY | THE UNIVERSITY OF TORONTO INNOVATIONS FOUNDATION (CA) | 1995-09-06 | — | — | EP | disclosed |
| US-5399671-A | Specifically crosslinked hemoglobin with free functionality | UNIVERSITY OF TORONTO INNOVATIONS FOUNDATION, THE (CA) | 1995-03-21 | — | — | US | disclosed |
| WO-1994011399-A1 | SPECIFICALLY CROSSLINKED HEMOGLOBIN WITH FREE FUNCTIONALITY | KLUGER RONALD (CA) | 1994-05-26 | — | — | WO | disclosed |