Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.58 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.54 |
| ▸ | F10 | P00742 | 1/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8068709 | 0.83 | PTGDR2 (0.52) | HDAC6HDAC1HDAC10HDAC8PTGDR2 | |
| SCHEMBL3085461 | 0.82 | PTGDR2 (0.81) | HDAC6HDAC1HDAC10HDAC8PTGDR2 | |
| SCHEMBL9615138 | 0.79 | HDAC6 (0.64) | HDAC6HDAC1HDAC10PTGDR2 | |
| SCHEMBL14890799 | 0.79 | ENPP2 (0.69) | PTGDR2F10 | |
| SCHEMBL14891077 | 0.78 | ENPP2 (0.56) | F10 | |
| SCHEMBL10154881 | 0.77 | HDAC6 (0.58) | HDAC6HDAC1HDAC10HDAC8PTGDR2 | |
| SCHEMBL7220006 | 0.77 | MAPT (0.54) | PTGDR2 | |
| SCHEMBL14489612 | 0.76 | F10 (0.73) | HDAC6HDAC1HDAC10HDAC8F10 | |
| SCHEMBL14891392 | 0.75 | ENPP2 (0.64) | HDAC6HDAC1PTGDR2 | |
| SCHEMBL14891339 | 0.75 | ENPP2 (0.61) | HDAC6HDAC1HDAC10HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1014991-A1 | PROSTAGLANDIN DERIVATIVES DEVOID OF SIDE-EFFECTS FOR THE TREATMENT OF GLAUCOMA | Pharmacia & Upjohn AB (SE) | 2000-07-05 | — | — | EP | disclosed |
| US-6057311-A | TREATING EATING DISORDERS | JAMES BLACK FOUNDATION LIMITED (GB) | 2000-05-02 | — | — | US | disclosed |
| WO-1999002165-A1 | PROSTAGLANDIN DERIVATIVES DEVOID OF SIDE-EFFECTS FOR THE TREATMENT OF GLAUCOMA | PHARMACIA & UPJOHN AB (SE) | 1999-01-21 | — | — | WO | disclosed |
| WO-1997032860-A1 | BENZODIAZONINE DERIVATIVES BINDING TO CHOLECYSTOKININ OR GASTRIN RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 1997-09-12 | — | — | WO | disclosed |