Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | CETP | P11597 | 1/20 | 0.39 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.35 |
| ▸ | CFD | P00746 | 1/20 | 0.35 |
| ▸ | F11 | P03951 | 1/20 | 0.35 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7746878 | 0.91 | CXCL8 (0.40) | PPARGPPARACETPCXCL8MEN1 | |
| SCHEMBL8059150 | 0.84 | CXCL8 (0.41) | CETPCXCL8MEN1NPC1RAB9A | |
| SCHEMBL8046809 | 0.81 | TDP1 (0.45) | CXCL8 | |
| SCHEMBL8061543 | 0.79 | MEN1 (0.40) | PPARGPPARACXCL8MEN1NPC1 | |
| SCHEMBL7050262 | 0.76 | PPARG (0.47) | PPARGPPARACETPMTNR1AMTNR1B | |
| SCHEMBL5054448 | 0.75 | PPARG (0.50) | PPARGPPARACETPMTNR1AMTNR1B | |
| SCHEMBL7744718 | 0.74 | TDP1 (0.47) | CXCL8 | |
| SCHEMBL7744435 | 0.73 | MEN1 (0.42) | CXCL8MEN1NPC1RAB9AKMT2A | |
| SCHEMBL5052957 | 0.72 | PPARG (0.45) | PPARGPPARACETPNPC1RAB9A | |
| SCHEMBL5053268 | 0.72 | FOLH1 (0.47) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046180-A | NAALADase inhibitors | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-04 | — | — | US | claimed |
| US-6046180-A | NAALADase inhibitors | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-04 | — | — | US | disclosed |