Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ACP3 | P15309 | 6/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8046809 | 0.91 | TDP1 (0.45) | TDP1ACP3L3MBTL1CXCL8KDM4E | |
| SCHEMBL8058479 | 0.86 | TDP1 (0.49) | TDP1ACP3L3MBTL1CXCL8KDM4E | |
| SCHEMBL7746878 | 0.80 | CXCL8 (0.40) | TDP1CXCL8 | |
| SCHEMBL7612146 | 0.78 | TDP1 (0.47) | TDP1ACP3KDM4EHPGD | |
| SCHEMBL7744762 | 0.76 | CXCL8 (0.40) | TDP1L3MBTL1CXCL8ALDH1A1 | |
| SCHEMBL8064207 | 0.75 | LMNA (0.40) | L3MBTL1CXCL8KDM4E | |
| SCHEMBL8057233 | 0.74 | PPARG (0.41) | CXCL8 | |
| SCHEMBL7053857 | 0.74 | ACP3 (0.48) | ACP3ALDH1A1 | |
| SCHEMBL915642 | 0.73 | ACP3 (0.68) | ACP3ALDH1A1 | |
| SCHEMBL5057868 | 0.73 | ACP3 (0.45) | ACP3HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002514160-A | — | — | 2002-05-14 | — | — | JP | claimed |
| US-6046180-A | NAALADase inhibitors | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-04 | — | — | US | claimed |
| EP-0936914-A4 | — | — | 1999-08-25 | — | — | EP | claimed |
| EP-0936914-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-08-25 | — | — | EP | claimed |
| WO-1997048400-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1997-12-24 | — | — | WO | claimed |
| US-6046180-A | NAALADase inhibitors | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-04 | — | — | US | disclosed |