Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | HTT | P42858 | 5/20 | 0.62 |
| ▸ | BRD4 | O60885 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.57 |
| ▸ | RELA | Q04206 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1764786 | 0.88 | MAPT (0.70) | MAPTLMNAHTTBRD4ALDH1A1 | |
| SCHEMBL19627035 | 0.83 | RAB9A (0.70) | MAPTLMNAHTTALDH1A1HPGD | |
| SCHEMBL14640404 | 0.81 | MAPT (0.61) | MAPTLMNAHTTBRD4ALDH1A1 | |
| SCHEMBL4455272 | 0.80 | LMNA (0.65) | MAPTLMNAHTTBRD4ALDH1A1 | |
| SCHEMBL3088586 | 0.80 | RECQL (0.63) | MAPTLMNAHTTBRD4ALDH1A1 | |
| SCHEMBL3140270 | 0.80 | SMN1; SMN2 (0.65) | MAPTLMNAHTTALDH1A1HPGD | |
| SCHEMBL2739995 | 0.79 | MAPT (0.65) | MAPTLMNAHTTBRD4ALDH1A1 | |
| SCHEMBL10061659 | 0.78 | MAPT (0.64) | MAPTLMNAHTTBRD4ALDH1A1 | |
| SCHEMBL2229720 | 0.78 | MAPT (0.63) | MAPTLMNAHTTBRD4MEN1 | |
| SCHEMBL2739994 | 0.78 | MAPT (0.63) | MAPTLMNAHTTBRD4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009090548-A2 | 3-AZABICYCLO [3.1.0] HEXANE DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | GLENMARK PHARMACEUTICALS, S.A. (US) | 2009-07-23 | — | — | WO | disclosed |
| WO-2009026197-A1 | NOVEL CATHEPSIN C INHIBITORS AND THEIR USE | GLAXO GROUP LIMITED (GB) | 2009-02-26 | — | — | WO | disclosed |