Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9182034 | 0.78 | MAPT (0.58) | KMT2AMEN1LMNAALDH1A1USP2 | |
| SCHEMBL9181212 | 0.76 | KMT2A (0.56) | KMT2AMEN1LMNAALDH1A1USP2 | |
| SCHEMBL9183149 | 0.76 | KMT2A (0.62) | KMT2AMEN1LMNAALDH1A1USP2 | |
| SCHEMBL9185511 | 0.75 | KMT2A (0.60) | KMT2AMEN1LMNAALDH1A1USP2 | |
| SCHEMBL9181883 | 0.75 | ADRB2 (0.65) | KMT2AMEN1LMNAALDH1A1USP2 | |
| SCHEMBL9180255 | 0.74 | ADRB2 (0.67) | KMT2AMEN1LMNAALDH1A1USP2 | |
| SCHEMBL9179435 | 0.74 | KMT2A (0.57) | KMT2AMEN1LMNAALDH1A1USP2 | |
| SCHEMBL9181745 | 0.74 | ABCB1 (0.64) | KMT2AMEN1LMNAALDH1A1USP2 | |
| SCHEMBL9183346 | 0.73 | ABCB1 (0.74) | KMT2AMEN1LMNAALDH1A1USP2 | |
| SCHEMBL11267673 | 0.73 | KDM4E (0.57) | KMT2AMEN1LMNAALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130217-A | ANTITUMOR | PFIZER INC (US) | 2000-10-10 | — | — | US | disclosed |
| WO-1994022846-A1 | COMPOUNDS ENHANCING ANTITUMOR ACTIVITY OF OTHER CYTOTOXIC AGENTS | PFIZER INC. (US) | 1994-10-13 | — | — | WO | disclosed |