Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | ILK | Q13418 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12109840 | 0.88 | ALDH1A1 (0.59) | ALDH1A1KDM4EHSD17B10MAPK1MAPT | |
| SCHEMBL10723297 | 0.84 | ALDH1A1 (0.79) | ALDH1A1KDM4EHSD17B10MAPTTSHR | |
| SCHEMBL13885581 | 0.83 | SMN1; SMN2 (0.59) | ALDH1A1KDM4EHSD17B10MAPK1MAPT | |
| SCHEMBL14970046 | 0.81 | HSD17B10 (0.54) | ALDH1A1KDM4EHSD17B10MAPK1MAPT | |
| SCHEMBL10721828 | 0.81 | SMN1; SMN2 (0.68) | ALDH1A1KDM4EHSD17B10MAPTTSHR | |
| SCHEMBL22439183 | 0.80 | KDM4E (0.53) | ALDH1A1KDM4EHSD17B10MAPK1MAPT | |
| SCHEMBL8040099 | 0.76 | SMN1; SMN2 (0.43) | ALDH1A1KDM4EHSD17B10MAPK1MAPT | |
| SCHEMBL2171428 | 0.76 | ALDH1A1 (0.59) | ALDH1A1KDM4EHSD17B10MAPK1MAPT | |
| SCHEMBL22439117 | 0.75 | ALDH1A1 (0.51) | ALDH1A1KDM4EHSD17B10MAPK1MAPT | |
| SCHEMBL8040086 | 0.72 | KDM4E (0.45) | ALDH1A1KDM4EHSD17B10MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130217-A | ANTITUMOR | PFIZER INC (US) | 2000-10-10 | — | — | US | disclosed |
| WO-1994022846-A1 | COMPOUNDS ENHANCING ANTITUMOR ACTIVITY OF OTHER CYTOTOXIC AGENTS | PFIZER INC. (US) | 1994-10-13 | — | — | WO | disclosed |