SCHEMBL8058484

SCHEMBL8058484

NC1=NC(C#Cc2ccccc2)Cc2ccsc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
NOS2 P35228 18/20 1.00
NOS3 P29474 15/20 0.67
GRM5 P41594 1/20 0.35
NOS1 P29475 1/20 0.33
KDM4E B2RXH2 1/20 0.32
MEN1 O00255 1/20 0.32
NPC1 O15118 1/20 0.32
ALDH1A1 P00352 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
MAPT P10636 1/20 0.32
CYP2C9 P11712 1/20 0.32
HPGD P15428 1/20 0.32
CYP2C19 P33261 1/20 0.32
KMT2A Q03164 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
HSD17B10 Q99714 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8099395 0.99 NOS2 (0.97) NOS2NOS3GRM5NOS1KDM4E
SCHEMBL8058482 0.80 NOS2 (1.00) NOS2NOS3NOS1KMT2A
Hydrochloric Acid SCHEMBL8104281 0.79 NOS2 (0.97) NOS2NOS3NOS1KMT2A
Hydrochloric Acid SCHEMBL8098216 0.79 NOS2 (0.65) NOS2NOS3
SCHEMBL8061062 0.77 NOS3 (0.63) NOS2NOS3KDM4EMEN1NPC1
SCHEMBL8056713 0.77 NOS2 (1.00) NOS2NOS3NOS1KMT2A
SCHEMBL8045565 0.77 NOS2 (1.00) NOS2NOS3NOS1KMT2A
Hydrochloric Acid SCHEMBL8106537 0.76 NOS3 (0.61) NOS2NOS3KDM4EMEN1NPC1
Hydrochloric Acid SCHEMBL8105913 0.76 NOS2 (0.97) NOS2NOS3NOS1
Hydrochloric Acid SCHEMBL8091025 0.76 NOS2 (0.97) NOS2NOS3NOS1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6046191-A PHARMACEUTICAL COMBINATION COMPRISING A COX-2 INHIBITOR OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND AN AMIDINE COMPOUND; FOR TREATMENT OF INFLAMMATORY DISORDERS ASTRA PHARMACEUTICALS LTD. (GB) 2000-04-04 US claimed
EP-0892784-A1 AMINOISOQUINOLINES AND AMINOTHIENOPYRIDINE DERIVATIVES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS Astra Pharmaceuticals Limited (GB) 1999-01-27 EP claimed
WO-1997038977-A1 AMINOISOQUINOLINES AND AMINOTHIENOPYRIDINE DERIVATIVES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS ASTRA PHARMACEUTICALS LTD. (GB) 1997-10-23 WO claimed
EP-1027052-A1 NOVEL COMBINATION AstraZeneca UK Limited (GB) 2000-08-16 EP disclosed
US-6046191-A PHARMACEUTICAL COMBINATION COMPRISING A COX-2 INHIBITOR OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND AN AMIDINE COMPOUND; FOR TREATMENT OF INFLAMMATORY DISORDERS ASTRA PHARMACEUTICALS LTD. (GB) 2000-04-04 US disclosed
WO-1999018960-A1 NOVEL COMBINATION ASTRAZENECA UK LIMITED (GB) 1999-04-22 WO disclosed