Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.44 |
| ▸ | RXRA | P19793 | 2/20 | 0.41 |
| ▸ | RXRB | P28702 | 2/20 | 0.41 |
| ▸ | RXRG | P48443 | 2/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8058552 | 1.00 | AKR1C3 (0.44) | AKR1C3RXRARXRBRXRGRPS6KA3 | |
| SCHEMBL7133171 | 0.84 | AKR1C3 (0.55) | AKR1C3PTGS1CES2APEX1TBXAS1 | |
| SCHEMBL7133176 | 0.84 | AKR1C3 (0.55) | AKR1C3PTGS1CES2APEX1TBXAS1 | |
| Guanidine SCHEMBL8058713 | 0.81 | RPS6KA3 (0.49) | AKR1C3RXRARXRBRXRGRPS6KA3 | |
| SCHEMBL8042956 | 0.77 | AKR1C3 (0.58) | AKR1C3LMNAMAPTHPGDCES2 | |
| SCHEMBL5004361 | 0.77 | AKR1C3 (0.58) | AKR1C3LMNAMAPTHPGDCES2 | |
| SCHEMBL12498144 | 0.76 | AKR1C3 (0.43) | AKR1C3RXRARXRBRXRGLMNA | |
| SCHEMBL12498149 | 0.76 | AKR1C3 (0.43) | AKR1C3RXRARXRBRXRGLMNA | |
| SCHEMBL6933101 | 0.76 | AKR1C3 (0.60) | AKR1C3PTGS1CES2NR4A1NR4A2 | |
| SCHEMBL6933104 | 0.76 | AKR1C3 (0.60) | AKR1C3PTGS1CES2NR4A1NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025349-A | ANTIARRHYTHMIC PROPERTIES, | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-02-15 | — | — | US | disclosed |