Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | RXRA | P19793 | 3/20 | 0.43 |
| ▸ | RXRB | P28702 | 3/20 | 0.43 |
| ▸ | RXRG | P48443 | 2/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18790570 | 0.82 | RPS6KA3 (0.59) | RPS6KA3JAK3RXRARXRBRXRG | |
| SCHEMBL8058552 | 0.81 | AKR1C3 (0.44) | RPS6KA3JAK3RXRARXRBRXRG | |
| SCHEMBL8058546 | 0.81 | AKR1C3 (0.44) | RPS6KA3JAK3RXRARXRBRXRG | |
| Hydrochloric Acid SCHEMBL8058717 | 0.81 | RPS6KA3 (0.46) | RPS6KA3JAK3CES2MAPTHPGD | |
| Guanidine SCHEMBL7158194 | 0.80 | AKR1C3 (0.46) | AKR1C3TBXAS1PTGS1 | |
| Guanidine SCHEMBL7158197 | 0.80 | AKR1C3 (0.46) | AKR1C3TBXAS1PTGS1 | |
| SCHEMBL5004361 | 0.75 | AKR1C3 (0.58) | AKR1C3CES2MAPTLMNAHPGD | |
| SCHEMBL8042956 | 0.75 | AKR1C3 (0.58) | AKR1C3CES2MAPTLMNAHPGD | |
| SCHEMBL12498144 | 0.74 | AKR1C3 (0.43) | RXRARXRBRXRGAKR1C3MAPT | |
| SCHEMBL12498149 | 0.74 | AKR1C3 (0.43) | RXRARXRBRXRGAKR1C3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025349-A | ANTIARRHYTHMIC PROPERTIES, | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-02-15 | — | — | US | disclosed |