Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ACP3 | P15309 | 5/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7612146 | 0.91 | TDP1 (0.47) | TDP1ACP3PTGER4PTGS2NR1H4 | |
| SCHEMBL8058516 | 0.84 | TDP1 (0.49) | TDP1ACP3PTGER4PTGS2NR1H4 | |
| SCHEMBL8061543 | 0.81 | MEN1 (0.40) | PTGS2NR1H4 | |
| SCHEMBL8046809 | 0.79 | TDP1 (0.45) | TDP1ACP3KDM4EHPGD | |
| SCHEMBL5053204 | 0.75 | GGH (0.50) | ACP3 | |
| SCHEMBL5060535 | 0.75 | ACP3 (0.46) | ACP3CMA1 | |
| SCHEMBL7744435 | 0.75 | MEN1 (0.42) | PTGS2NR1H4 | |
| SCHEMBL7744718 | 0.72 | TDP1 (0.47) | TDP1ACP3KDM4EHPGD | |
| SCHEMBL8057208 | 0.70 | PTGS2 (0.39) | PTGS2NR1H4 | |
| SCHEMBL5058028 | 0.70 | FOLH1 (0.50) | ACP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046180-A | NAALADase inhibitors | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-04 | — | — | US | disclosed |