Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | GLS | O94925 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5054362 | 0.89 | HPGDS (0.38) | HPGDSSMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL5060251 | 0.86 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPTMEN1KMT2AKDM4E | |
| SCHEMBL5059954 | 0.82 | ACP3 (0.44) | L3MBTL1MCL1TDP1CYP1A2 | |
| SCHEMBL7606891 | 0.81 | PARP1 (0.42) | HPGDSSMN1; SMN2MAPTKDM4EPARP1 | |
| SCHEMBL5054472 | 0.81 | ALDH1A1 (0.47) | SMN1; SMN2MAPTMEN1KMT2AKDM4E | |
| SCHEMBL8520179 | 0.80 | SRC (0.39) | SMN1; SMN2MAPTMEN1KMT2APARP1 | |
| SCHEMBL7608451 | 0.78 | HPGDS (0.40) | HPGDSMEN1KMT2APOLBMCL1 | |
| SCHEMBL5054488 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPTMEN1KMT2AKDM4E | |
| SCHEMBL7053859 | 0.77 | ACP3 (0.43) | MCL1TDP1 | |
| SCHEMBL5054433 | 0.76 | ACP3 (0.43) | MCL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1005348-A1 | NAALADASE COMPOSITIONS AND METHODS FOR TREATING GLUTAMATE ABNORMALITY AND EFFECTING NEURONAL ACTIVITY IN ANIMALS | GUILFORD PHARMACEUTICALS INC. (US) | 2000-06-07 | — | — | EP | disclosed |
| WO-1998013046-A1 | NAALADASE COMPOSITIONS AND METHODS FOR TREATING GLUTAMATE ABNORMALITY AND EFFECTING NEURONAL ACTIVITY IN ANIMALS | GUILFORD PHARMACEUTICALS INC. (US) | 1998-04-02 | — | — | WO | disclosed |