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SCHEMBL8058915

SCHEMBL8058915

CSCC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C)[C@@H](C)O

nearest known ligand 0.64

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ TFPI P10646 1/20 0.54
▸ IL23R Q5VWK5 6/20 0.53
▸ GLP1R P43220 2/20 0.52
▸ GCGR P47871 1/20 0.52
▸ GIPR P48546 1/20 0.52
▸ VIPR2 P41587 1/20 0.51
▸ NPY4R P50391 5/20 0.50
▸ NPY1R P25929 4/20 0.50
▸ NPY2R P49146 4/20 0.50
▸ NPY5R Q15761 4/20 0.50
▸ CCKBR P32239 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8058908 1.00 TFPI (0.54) TFPIIL23RGLP1RGCGRGIPR
SCHEMBL10428709 0.96 IL23R (0.54) TFPIIL23RGLP1RGCGRGIPR
SCHEMBL10428706 0.96 IL23R (0.54) TFPIIL23RGLP1RGCGRGIPR
SCHEMBL31498888 0.89 TFPI (0.62) TFPIIL23RGLP1RGCGRGIPR
SCHEMBL29512407 0.88 NPY4R (0.58) TFPIIL23RVIPR2NPY4RNPY1R
SCHEMBL18613838 0.87 NPY4R (0.60) IL23RNPY4RNPY1RNPY2RNPY5R
SCHEMBL18613835 0.87 NPY4R (0.60) IL23RNPY4RNPY1RNPY2RNPY5R
SCHEMBL29649202 0.87 IL23R (0.60) TFPIIL23RGLP1RGCGRGIPR
SCHEMBL29794100 0.87 TFPI (0.67) TFPIIL23RGLP1RGCGRGIPR
SCHEMBL31182635 0.86 GLP1R (0.64) TFPIGLP1RGCGRGIPRVIPR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0379511-A1 POLYPEPTIDES WITH LAMININ ACTIVITY. UNIV MINNESOTA (US) 1990-08-01 — — EP claimed
WO-1989001493-A1 POLYPEPTIDES WITH LAMININ ACTIVITY REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 1989-02-23 — — WO claimed
EP-1003561-A2 LATENT REACTIVE POLYMERS WITH BIOLOGICALLY ACTIVE MOIETIES SurModics, Inc. (US) 2000-05-31 — — EP disclosed
WO-1999008717-A2 LATENT REACTIVE POLYMERS WITH BIOLOGICALLY ACTIVE MOIETIES SURMODICS, INC. (US) 1999-02-25 — — WO disclosed
EP-0379511-A1 POLYPEPTIDES WITH LAMININ ACTIVITY. UNIV MINNESOTA (US) 1990-08-01 — — EP disclosed
WO-1989001493-A1 POLYPEPTIDES WITH LAMININ ACTIVITY REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 1989-02-23 — — WO disclosed
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