Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8058460 | 0.91 | HPGD (0.43) | HPGDHSD17B10KDM4EALOX15SMN1; SMN2 | |
| SCHEMBL8059138 | 0.89 | HPGD (0.46) | HPGDHSD17B10KDM4EALOX15SMN1; SMN2 | |
| SCHEMBL28528763 | 0.76 | HPGD (0.50) | HPGDHSD17B10SMN1; SMN2ALDH1A1GLA | |
| SCHEMBL28512364 | 0.72 | CHRM2 (0.47) | HPGDALDH1A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8058503 | 0.72 | HPGD (0.46) | HPGDHSD17B10SMN1; SMN2ALDH1A1GLA | |
| SCHEMBL8058463 | 0.71 | HPGD (0.43) | HPGDSMN1; SMN2ALDH1A1GLAALOX12 | |
| SCHEMBL16861247 | 0.68 | HPGD (0.45) | HPGDSMN1; SMN2 | |
| SCHEMBL9187056 | 0.67 | TSHR (0.41) | HPGDSMN1; SMN2ALDH1A1ALOX12KMT2A | |
| SCHEMBL10339859 | 0.67 | ALDH1A1 (0.41) | HPGDSMN1; SMN2ALDH1A1ALOX12KMT2A | |
| SCHEMBL10979372 | 0.66 | PKM (0.39) | HPGDKDM4EALDH1A1CYP2C9PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046180-A | NAALADase inhibitors | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-04 | — | — | US | disclosed |
| EP-0936914-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-08-25 | — | — | EP | disclosed |
| EP-0936914-A4 | — | — | 1999-08-25 | — | — | EP | disclosed |
| WO-1997048400-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1997-12-24 | — | — | WO | disclosed |