Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 10/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.36 |
| ▸ | PTGIR | P43119 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8054796 | 0.83 | KIF11 (0.49) | KIF11TAAR1MAPK1CYP2C19HIF1A | |
| SCHEMBL7568129 | 0.79 | KIF11 (0.46) | KIF11TAAR1TBXA2RPTGIRCYP2C19 | |
| SCHEMBL248982 | 0.78 | KIF11 (0.63) | KIF11 | |
| SCHEMBL8409738 | 0.77 | KCNN4 (0.41) | KIF11TAAR1MAPK1CYP2C19ALDH1A1 | |
| SCHEMBL7561243 | 0.72 | CYP1A2 (0.57) | KIF11TAAR1MAPK1CYP2C19ALDH1A1 | |
| SCHEMBL19830932 | 0.70 | KIF11 (0.47) | KIF11ALDH1A1 | |
| SCHEMBL1537242 | 0.69 | KIF11 (0.57) | KIF11TBXA2RPTGIRCYP2C19HIF1A | |
| SCHEMBL21645182 | 0.68 | KIF11 (0.37) | KIF11TAAR1MAPK1TBXA2RPTGIR | |
| SCHEMBL17576267 | 0.67 | ALDH1A1 (0.46) | KIF11TAAR1MAPK1CYP2C19HIF1A | |
| SCHEMBL5012487 | 0.67 | TAAR1 (0.43) | KIF11TAAR1MAPK1CYP2C19HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043264-A | A THROMBOXANE A2 RECEPTOR ANTAGONIST FOR TREATING HYPERTENSION, THROMBOSIS, ISCHEMIC HEART DISEASES, CIRCULATORY DISEASES, ARTERIOSCLEROSIS, PLATELET FUNCTION DISORDER, HYPERLIPIDEMIA, NEPHRITIS OR ASTHMA | TORAY INDUSTRIES, INC. (JP) | 2000-03-28 | — | — | US | disclosed |
| EP-0751126-A1 | BENZENE-FUSED HETEROCYCLIC DERIVATIVE AND USE OF THE SAME | TORAY INDUSTRIES, INC. (JP) | 1997-01-02 | — | — | EP | disclosed |