Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPP1R15A | O75807 | 1/20 | 0.40 |
| ▸ | MELK | Q14680 | 1/20 | 0.40 |
| ▸ | PPP1R15B | Q5SWA1 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30275282 | 0.79 | L3MBTL1 (0.59) | PPP1R15AMELKPPP1R15BNPSR1L3MBTL1 | |
| SCHEMBL6847216 | 0.79 | L3MBTL1 (0.59) | PPP1R15AMELKPPP1R15BNPSR1L3MBTL1 | |
| SCHEMBL11959499 | 0.79 | CA2 (0.33) | MAOBGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL3972367 | 0.72 | GRIN2D (0.42) | PPP1R15AMELKPPP1R15BNPSR1L3MBTL1 | |
| SCHEMBL379834 | 0.70 | GRIN1 (0.57) | NPSR1MAOBSMN1; SMN2GRIN2DGRIN3B | |
| SCHEMBL379833 | 0.70 | GRIN1 (0.57) | NPSR1MAOBSMN1; SMN2GRIN2DGRIN3B | |
| SCHEMBL11111610 | 0.69 | NPSR1 (0.38) | PPP1R15AMELKPPP1R15BNPSR1L3MBTL1 | |
| SCHEMBL3697881 | 0.68 | GAA (0.44) | PPP1R15AMELKPPP1R15BNPSR1L3MBTL1 | |
| SCHEMBL10613416 | 0.64 | SLC22A1 (0.57) | NPSR1MAOBSMN1; SMN2SLC22A1HTR1A | |
| SCHEMBL11887770 | 0.64 | SLC22A1 (0.57) | NPSR1MAOBSMN1; SMN2SLC22A1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037410-A2 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | ARAGON PHARMACEUTICALS, INC. (US) | 2012-03-22 | — | — | WO | disclosed |