SCHEMBL8059616

SCHEMBL8059616

OP(c1ccc(F)cc1)c1ccc(F)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ORAI1 Q96D31 1/20 0.39
ORAI2 Q96SN7 1/20 0.39
ORAI3 Q9BRQ5 1/20 0.39
TRPV6 Q9H1D0 1/20 0.39
CES2 O00748 1/20 0.39
CES1 P23141 1/20 0.39
CA1 P00915 3/20 0.38
CA2 P00918 3/20 0.38
CA7 P43166 1/20 0.38
CA9 Q16790 1/20 0.38
ACHE P22303 1/20 0.38
ALDH1A1 P00352 1/20 0.37
SLC22A2 O15244 1/20 0.35
SLC22A1 O15245 1/20 0.35
SLC22A3 O75751 1/20 0.35
PLAU P00749 1/20 0.35
IDO1 P14902 2/20 0.34
GAA P10253 1/20 0.34
MEN1 O00255 1/20 0.33
LMNA P02545 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12621055 0.81 ORAI1 (0.39) ORAI1ORAI2ORAI3TRPV6CES2
SCHEMBL196718 0.73 CYP3A4 (0.44) ORAI1ORAI2ORAI3TRPV6CES2
SCHEMBL5713320 0.71 CYP3A4 (0.42) ORAI1ORAI2ORAI3TRPV6CES2
SCHEMBL7933208 0.71 CA1 (0.40) ORAI1ORAI2ORAI3TRPV6CES2
SCHEMBL31328588 0.71 CYP3A4 (0.36) ORAI1ORAI2ORAI3TRPV6CES2
SCHEMBL8654887 0.69 EPHX2 (0.46) ORAI1ORAI2ORAI3TRPV6CES2
SCHEMBL2153517 0.69 CA1 (0.38) ORAI1ORAI2ORAI3TRPV6CES2
SCHEMBL10340766 0.69 IDO1 (0.39) ORAI1ORAI2ORAI3TRPV6CES2
SCHEMBL2886150 0.69 IDO1 (0.39) ORAI1ORAI2ORAI3TRPV6CES2
Hydrochloric Acid SCHEMBL21724713 0.69 CYP3A4 (0.40) ORAI1ORAI2ORAI3TRPV6CES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6077968-A Process for the preparation of alkyl arylphosphinites CELANESE GMBH (DE) 2000-06-20 US disclosed
EP-0739333-B1 SELECTIVE ASYMMETRIC HYDROGENATION OF DEHYDROAMINO ACID DERIVATIVES USING RHODIUM AND IRIDIUM DIPHOSPHINITE CARBOHYDRATE CATALYST COMPOSITIONS DU PONT (US) 1998-10-14 EP disclosed
US-5705669-A DEHYDROHALOGENATION A HALOPHOSPHINE, REACTION WITH ALCOHOL AND NEUTRALIZATION WITH ALCOHOL HOECHST AKTIENGESELLSCHAFT (DE) 1998-01-06 US disclosed
EP-0739333-A1 SELECTIVE ASYMMETRIC HYDROGENATION OF DEHYDROAMINO ACID DERIVATIVES USING RHODIUM AND IRIDIUM DIPHOSPHINITE CARBOHYDRATE CATALYST COMPOSITIONS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1996-10-30 EP disclosed
US-5510507-A COORDINATION CATALYSTS; EFFICIENT ENANTIOSELECTIVITY E. I. DU PONT DE NEMOURS AND COMPANY (US) 1996-04-23 US disclosed
US-5481006-A PREPARATION OF INTERMEDIATES FOR PHARMACEUTICALS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1996-01-02 US disclosed
WO-1995018787-A1 SELECTIVE ASYMMETRIC HYDROGENATION OF DEHYDROAMINO ACID DERIVATIVES USING RHODIUM AND IRIDIUM DIPHOSPHINITE CARBOHYDRATE CATALYST COMPOSITIONS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1995-07-13 WO disclosed