Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.70 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.70 |
| ▸ | TRPM2 | O94759 | 2/20 | 0.57 |
| ▸ | MAOB | P27338 | 3/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8059645 | 1.00 | TRPA1 (0.70) | TRPA1TRPM8TRPM2MAOBEGFR | |
| SCHEMBL8061782 | 0.91 | TRPA1 (0.70) | TRPA1TRPM8TRPM2MAOBEGFR | |
| SCHEMBL8061780 | 0.91 | TRPA1 (0.70) | TRPA1TRPM8TRPM2MAOBEGFR | |
| SCHEMBL8065883 | 0.89 | TRPA1 (0.75) | TRPA1TRPM8TRPM2EGFRMEN1 | |
| SCHEMBL8065880 | 0.89 | TRPA1 (0.75) | TRPA1TRPM8TRPM2EGFRMEN1 | |
| SCHEMBL8065358 | 0.87 | KDM4E (0.60) | TRPA1TRPM8TRPM2MAOBEGFR | |
| SCHEMBL8065360 | 0.87 | KDM4E (0.60) | TRPA1TRPM8TRPM2MAOBEGFR | |
| SCHEMBL8065971 | 0.86 | TRPA1 (0.68) | TRPA1TRPM8TRPM2EGFRMEN1 | |
| SCHEMBL8065974 | 0.86 | TRPA1 (0.68) | TRPA1TRPM8TRPM2EGFRMEN1 | |
| SCHEMBL8060457 | 0.85 | EGFR (0.75) | TRPA1TRPM8TRPM2MAOBEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127392-A | A MUSCLE RELAXANT FOR TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION; INOTROPIC AGENT | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-10-03 | — | — | US | disclosed |
| US-6046239-A | USED IN THE TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION, VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION SUCH AS URINARY INCONTINENCE, ASTHMA, ANGINA, PREMATURE LABOR, CONGESTIVE HEART FAILURE | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-04-04 | — | — | US | disclosed |